Near-infrared photoactivatable nitric oxide donors with photoacoustic readout

Effie Y. Zhou, Hailey J. Knox, Christopher J. Reinhardt, Gina Partipilo, Jefferson Chan

Research output: Chapter in Book/Report/Conference proceedingChapter


In this chapter, we motivate the need for photoactivatable NO donor molecules and give a brief survey of the existing chemical tools in the field. We then provide detailed protocols for the synthesis and validation of a near-infrared light-activated NO donor molecule, photoNOD-1, developed in our research group. With this tool, NO can be released in vivo in a radiation-dependent manner that can be monitored using photoacoustic imaging.

Original languageEnglish (US)
Title of host publicationMethods in Enzymology
EditorsDavid M. Chenoweth
PublisherAcademic Press Inc.
Number of pages35
ISBN (Print)9780128211564
StatePublished - 2020

Publication series

NameMethods in Enzymology
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988


  • Donors
  • Near-infrared
  • Nitric oxide
  • Photoacoustic imaging
  • Photoactivation
  • Real-time monitoring

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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