Near-infrared photoactivatable nitric oxide donors with photoacoustic readout

Effie Y. Zhou, Hailey J. Knox, Christopher J. Reinhardt, Gina Partipilo, Jefferson Chan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter, we motivate the need for photoactivatable NO donor molecules and give a brief survey of the existing chemical tools in the field. We then provide detailed protocols for the synthesis and validation of a near-infrared light-activated NO donor molecule, photoNOD-1, developed in our research group. With this tool, NO can be released in vivo in a radiation-dependent manner that can be monitored using photoacoustic imaging.

Original languageEnglish (US)
Title of host publicationMethods in Enzymology
PublisherAcademic Press Inc.
DOIs
StateAccepted/In press - Jan 1 2020

Publication series

NameMethods in Enzymology
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988

Keywords

  • Donors
  • Near-infrared
  • Nitric oxide
  • Photoacoustic imaging
  • Photoactivation
  • Real-time monitoring

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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  • Cite this

    Zhou, E. Y., Knox, H. J., Reinhardt, C. J., Partipilo, G., & Chan, J. (Accepted/In press). Near-infrared photoactivatable nitric oxide donors with photoacoustic readout. In Methods in Enzymology (Methods in Enzymology). Academic Press Inc.. https://doi.org/10.1016/bs.mie.2020.05.003