Abstract

Optical coherence tomography (OCT) images of biological tissues often have low contrast. Spectroscopic optical coherence tomography (SOCT) methods have been developed to enhance contrast but remain limited because most tissues are not spectrally active in the frequency bands of laser sources commonly used in OCT. Near-infrared (NIR) dyes with absorption spectra features within the OCT source spectrum can be used for enhancing contrast in this situation. We introduce and demonstrate the use of NIR dyes as contrast agents for SOCT. Contrast-enhanced images are compared with fluorescence microscopy, demonstrating a link between SOCT and fluorescence imaging.

Original languageEnglish (US)
Pages (from-to)1647-1649
Number of pages3
JournalOptics Letters
Volume29
Issue number14
DOIs
StatePublished - Jul 15 2004

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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