Naturally derived biomaterials for addressing inflammation in tissue regeneration

Rebecca A. Hortensius, Brendan A.C. Harley

Research output: Contribution to journalReview articlepeer-review


Tissue regeneration strategies have traditionally relied on designing biomaterials that closely mimic features of the native extracellular matrix (ECM) as a means to potentially promote site-specific cellular behaviors. However, inflammation, while a necessary component of wound healing, can alter processes associated with successful tissue regeneration following an initial injury. These processes can be further magnified by the implantation of a biomaterial within the wound site. In addition to designing biomaterials to satisfy biocompatibility concerns as well as to replicate elements of the composition, structure, and mechanics of native tissue, we propose that ECM analogs should also include features that modulate the inflammatory response. Indeed, strategies that enhance, reduce, or even change the temporal phenotype of inflammatory processes have unique potential as future pro-regenerative analogs. Here, we review derivatives of three natural materials with intrinsic anti-inflammatory properties and discuss their potential to address the challenges of inflammation in tissue engineering and chronic wounds.

Original languageEnglish (US)
Pages (from-to)1015-1024
Number of pages10
JournalExperimental Biology and Medicine
Issue number10
StatePublished - May 2016


  • Amniotic membrane
  • Biomaterial
  • Chitosan
  • Decellularized matrix
  • Inflammation
  • Tissue regeneration

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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