Naturally amplified player for biosensing: tmRNA to the rescue

Ott Scheler, Lauris Kaplinski, Barry Glynn, Ryan C. Bailey, Ants Kurg

Research output: Contribution to journalConference articlepeer-review

Abstract

We present a trans-translation mediating tmRNA molecule from bacteria that can be used as a marker in microbial diagnostics and/or taxonomical studies. Different bacteria can be detected and specifically identified using surface bound complementary DNA oligonucleotide probes on different sensor platforms. Several tmRNA hybridization techniques were studied on microarray and in real-time on SOI microring resonator biosensor platforms. Microarray based detection technology enabled detection of tmRNA molecules from less than 1 cell equivalent of pathogenic bacteria.

Original languageEnglish (US)
Pages (from-to)1549-1552
Number of pages4
JournalProcedia Engineering
Volume25
DOIs
StatePublished - 2011
Event25th Eurosensors Conference - Athens, Greece
Duration: Sep 4 2011Sep 7 2011

Keywords

  • Microarray
  • Molecular diagnostics
  • NASBA
  • SOI microring resonators
  • TmRNA

ASJC Scopus subject areas

  • Engineering(all)

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