Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain

Neil R. Smalheiser, Giovanni Lugli, Vetle I. Torvik, Nathan Mise, Rieko Ikeda, Kuniya Abe

Research output: Contribution to journalArticle

Abstract

Natural antisense transcripts and overlapping sense transcripts are expressed in a variety of tissues, including adult mouse brain. Here we show that a subset of mRNA-like sense-antisense transcript pairs are co-expressed within synaptoneurosomes of adult mouse forebrain, a subcellular fraction that is enriched in pinched-off dendritic spines of pyramidal neurons. Several of these pairs involve mRNAs that have been implicated in synaptic functions and in Alzheimer disease pathways. This study provides evidence that a new class of noncoding RNAs (natural antisense transcripts) are expressed near synapses, and encourages further studies of their roles in neuronal function.

Original languageEnglish (US)
Pages (from-to)236-239
Number of pages4
JournalNeuroscience Research
Volume62
Issue number4
DOIs
StatePublished - Dec 1 2008

Keywords

  • Antisense RNA
  • RNA interference
  • Synaptic plasticity
  • Transcriptome

ASJC Scopus subject areas

  • Neuroscience(all)

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