Abstract
Natural antisense transcripts and overlapping sense transcripts are expressed in a variety of tissues, including adult mouse brain. Here we show that a subset of mRNA-like sense-antisense transcript pairs are co-expressed within synaptoneurosomes of adult mouse forebrain, a subcellular fraction that is enriched in pinched-off dendritic spines of pyramidal neurons. Several of these pairs involve mRNAs that have been implicated in synaptic functions and in Alzheimer disease pathways. This study provides evidence that a new class of noncoding RNAs (natural antisense transcripts) are expressed near synapses, and encourages further studies of their roles in neuronal function.
Original language | English (US) |
---|---|
Pages (from-to) | 236-239 |
Number of pages | 4 |
Journal | Neuroscience Research |
Volume | 62 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2008 |
Externally published | Yes |
Keywords
- Antisense RNA
- RNA interference
- Synaptic plasticity
- Transcriptome
ASJC Scopus subject areas
- General Neuroscience