Nanovacuums: Nanoparticle uptake and differential cellular migration on a carpet of nanoparticles

Jie An Yang, Hoa Tri Phan, Shruti Vaidya, Catherine J. Murphy

Research output: Contribution to journalArticle

Abstract

The behavior of prostate carcinoma (PC3) cells and human dermal fibroblast (HDF) cells when incubated with sedimented Au NPs in vitro is studied. Darkfield microscopy demonstrates that both PC3 and HDF cells can "vacuum" Au NPs from the surface. Mean square displacement and mean cumulative square distance of cells shows that PC3 migration decreases in the presence of Au NPs while for HDF, migration is dependent on the surface charge and shape of Au NPs.

Original languageEnglish (US)
Pages (from-to)2295-2302
Number of pages8
JournalNano letters
Volume13
Issue number5
DOIs
StatePublished - May 8 2013

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Keywords

  • cellular
  • Gold
  • migration
  • nanocrystals
  • nanoparticles
  • uptake

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

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