Nanostructured Lipid-Based Films for Substrate-Mediated Applications in Biotechnology

Minjee Kang, Mohit Tuteja, Andrea Centrone, Daniel Topgaard, Cecilia Leal

Research output: Contribution to journalArticlepeer-review

Abstract

Amphiphilic in nature, lipids spontaneously self-assemble into a range of nanostructures in the presence of water. Among lipid self-assembled structures, liposomes and supported lipid bilayers have long held scientific interest for their main applications in drug delivery and plasma membrane models, respectively. In contrast, lipid-based multilayered membranes on solid supports only recently begin drawing scientists' attention. Current studies show that the stacking of multiple bilayers on a solid support yields cooperative structural and dynamic behavior that enables new functionalities. Lipid films provide compartmentalization, templating, and enhanced release of molecules of interest. Importantly, supported lipid phases exhibit long-range periodic nanoscale order and orientation that is tunable in response to a changing environment. Herein, the current understanding of lipid-based film research is summarized focusing on how unique structural characteristics enable the emergence of new applications including label-free biosensors, macroscale drug delivery, and substrate-mediated gene delivery. The authors' recent contributions focusing on the structural characterization of lipid-based films using small-angle X-ray scattering and atomic force microscopy are highlighted. In addition, new photothermally induced resonance and solid-state nuclear magnetic resonance data are described, providing insights into drug partition in lipid-based films as well as structure and dynamics at the molecular scale.

Original languageEnglish (US)
Article number1704356
JournalAdvanced Functional Materials
Volume28
Issue number9
DOIs
StatePublished - Feb 28 2018

Keywords

  • lipid films
  • lipid–polymer hybrids
  • solid-state NMR
  • substrate-mediated delivery
  • supported membranes

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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