TY - JOUR
T1 - Nanostructured Lipid-Based Films for Substrate-Mediated Applications in Biotechnology
AU - Kang, Minjee
AU - Tuteja, Mohit
AU - Centrone, Andrea
AU - Topgaard, Daniel
AU - Leal, Cecilia
N1 - Funding Information:
This work was supported by the National Science Foundation under Grant No. DMR-1554435 (phase behavior) and the National Institutes of Health under Grant No. 1DP2EB024377-01 (drug release). M.T. acknowledges support under the Cooperative Research Agreement between the University of Maryland and the National Institute of Standards and Technology Center for Nanoscale Science and Technology, Award 70NANB14H209, through the University of Maryland.
Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/2/28
Y1 - 2018/2/28
N2 - Amphiphilic in nature, lipids spontaneously self-assemble into a range of nanostructures in the presence of water. Among lipid self-assembled structures, liposomes and supported lipid bilayers have long held scientific interest for their main applications in drug delivery and plasma membrane models, respectively. In contrast, lipid-based multilayered membranes on solid supports only recently begin drawing scientists' attention. Current studies show that the stacking of multiple bilayers on a solid support yields cooperative structural and dynamic behavior that enables new functionalities. Lipid films provide compartmentalization, templating, and enhanced release of molecules of interest. Importantly, supported lipid phases exhibit long-range periodic nanoscale order and orientation that is tunable in response to a changing environment. Herein, the current understanding of lipid-based film research is summarized focusing on how unique structural characteristics enable the emergence of new applications including label-free biosensors, macroscale drug delivery, and substrate-mediated gene delivery. The authors' recent contributions focusing on the structural characterization of lipid-based films using small-angle X-ray scattering and atomic force microscopy are highlighted. In addition, new photothermally induced resonance and solid-state nuclear magnetic resonance data are described, providing insights into drug partition in lipid-based films as well as structure and dynamics at the molecular scale.
AB - Amphiphilic in nature, lipids spontaneously self-assemble into a range of nanostructures in the presence of water. Among lipid self-assembled structures, liposomes and supported lipid bilayers have long held scientific interest for their main applications in drug delivery and plasma membrane models, respectively. In contrast, lipid-based multilayered membranes on solid supports only recently begin drawing scientists' attention. Current studies show that the stacking of multiple bilayers on a solid support yields cooperative structural and dynamic behavior that enables new functionalities. Lipid films provide compartmentalization, templating, and enhanced release of molecules of interest. Importantly, supported lipid phases exhibit long-range periodic nanoscale order and orientation that is tunable in response to a changing environment. Herein, the current understanding of lipid-based film research is summarized focusing on how unique structural characteristics enable the emergence of new applications including label-free biosensors, macroscale drug delivery, and substrate-mediated gene delivery. The authors' recent contributions focusing on the structural characterization of lipid-based films using small-angle X-ray scattering and atomic force microscopy are highlighted. In addition, new photothermally induced resonance and solid-state nuclear magnetic resonance data are described, providing insights into drug partition in lipid-based films as well as structure and dynamics at the molecular scale.
KW - lipid films
KW - lipid–polymer hybrids
KW - solid-state NMR
KW - substrate-mediated delivery
KW - supported membranes
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U2 - 10.1002/adfm.201704356
DO - 10.1002/adfm.201704356
M3 - Article
AN - SCOPUS:85040225789
SN - 1616-301X
VL - 28
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 9
M1 - 1704356
ER -