Nanoscale studies of protein-membrane interactions in blood clotting

J. H. Morrissey, E. Tajkhorshid, C. M. Rienstra

Research output: Contribution to journalReview articlepeer-review

Abstract

Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
JournalJournal of Thrombosis and Haemostasis
Volume9
Issue number1 S
DOIs
StatePublished - Jul 2011

Keywords

  • Gla domains
  • Membranes
  • Phosphatidylserine
  • Phospholipids

ASJC Scopus subject areas

  • Hematology

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