Nanoscale studies of protein-membrane interactions in blood clotting

J. H. Morrissey, E. Tajkhorshid, C. M. Rienstra

Research output: Contribution to journalReview article

Abstract

Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
JournalJournal of Thrombosis and Haemostasis
Volume9
Issue number1 S
DOIs
StatePublished - Jul 1 2011

Keywords

  • Gla domains
  • Membranes
  • Phosphatidylserine
  • Phospholipids

ASJC Scopus subject areas

  • Hematology

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