Nanoscale nuclear architecture for cancer diagnosis by spatialdomain low-coherence quantitative phase microscopy

Pin Wang, Rajan K. Bista, Walid E. Khalbuss, Wei Qiu, Kevin D. Staton, Lin Zhang, Teresa A. Brentnall, Randall E. Brand, Yang Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Alterations in nuclear architecture are the hallmark diagnostic characteristic of cancer cells. In this work, we show that the nuclear architectural characteristics quantified by spatial-domain low-coherence quantitative phase microscopy (SL-QPM), is more sensitive for the identification of cancer cells than conventional cytopathology. We demonstrated the importance of nuclear architectural characteristics in both an animal model of intestinal carcinogenesis - APC/Min mouse model and human cytology specimens with colorectal cancer by identifying cancer from cytologically non-cancerous appearing cells. The determination of nanoscale nuclear architecture using this simple and practical optical instrument is a significant advance towards cancer diagnosis.

Original languageEnglish (US)
Title of host publicationBiomedical Applications of Light Scattering V
StatePublished - 2011
Externally publishedYes
EventBiomedical Applications of Light Scattering V - San Francisco, CA, United States
Duration: Jan 22 2011Jan 24 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceBiomedical Applications of Light Scattering V
Country/TerritoryUnited States
CitySan Francisco, CA


  • Cancer diagnosis
  • Cytopathology
  • Nanoscale nuclear architecture
  • Quantitative phase microscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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