@inproceedings{614c3aca7eb44c60897363b8ef536d51,
title = "Nanoscale nuclear architecture for cancer diagnosis by spatialdomain low-coherence quantitative phase microscopy",
abstract = "Alterations in nuclear architecture are the hallmark diagnostic characteristic of cancer cells. In this work, we show that the nuclear architectural characteristics quantified by spatial-domain low-coherence quantitative phase microscopy (SL-QPM), is more sensitive for the identification of cancer cells than conventional cytopathology. We demonstrated the importance of nuclear architectural characteristics in both an animal model of intestinal carcinogenesis - APC/Min mouse model and human cytology specimens with colorectal cancer by identifying cancer from cytologically non-cancerous appearing cells. The determination of nanoscale nuclear architecture using this simple and practical optical instrument is a significant advance towards cancer diagnosis.",
keywords = "Cancer diagnosis, Cytopathology, Nanoscale nuclear architecture, Quantitative phase microscopy",
author = "Pin Wang and Bista, {Rajan K.} and Khalbuss, {Walid E.} and Wei Qiu and Staton, {Kevin D.} and Lin Zhang and Brentnall, {Teresa A.} and Brand, {Randall E.} and Yang Liu",
year = "2011",
doi = "10.1117/12.874693",
language = "English (US)",
isbn = "9780819484444",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Biomedical Applications of Light Scattering V",
note = "Biomedical Applications of Light Scattering V ; Conference date: 22-01-2011 Through 24-01-2011",
}