Nanoscale insight into the degradation mechanisms of the cartilage articulating surface preceding OA

Tooba Shoaib, Catherine Yuh, Markus A. Wimmer, Thomas M. Schmid, Rosa M. Espinosa-Marzal

Research output: Contribution to journalArticlepeer-review

Abstract

Osteoarthritis (OA) is a degenerative joint disease and a leading cause of disability globally. In OA, the articulating surface of cartilage is compromised by fissures and cracks, and sometimes even worn away completely. Due to its avascular nature, articular cartilage has a poor self-healing ability, and therefore, understanding the mechanisms underlying degradation is key for OA prevention and for optimal design of replacements. In this work, the articulating surface of bovine cartilage was investigated in an environment with enhanced calcium concentration -as often found in cartilage in relation to OA- by combining atomic force microscopy, spectroscopy and an extended surface forces apparatus for the first time. The experimental results reveal that increased calcium concentration irreversibly weakens the cartilage's surface layer, and promotes stiction and high friction. The synergistic effect of calcium on altering the cartilage surface's structural, mechanical and frictional properties is proposed to compromise cartilage integrity at the onset of OA. Furthermore, two mechanisms at the molecular level based on the influence of calcium on lubricin and on the aggregation of the cartilage's matrix, respectively, are identified. The results of this work might not only help prevent OA but also help design better cartilage replacements.

Original languageEnglish (US)
Pages (from-to)3944-3955
Number of pages12
JournalBiomaterials Science
Volume8
Issue number14
DOIs
StatePublished - Jul 21 2020

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

Fingerprint Dive into the research topics of 'Nanoscale insight into the degradation mechanisms of the cartilage articulating surface preceding OA'. Together they form a unique fingerprint.

Cite this