Nanorainbow in integrated microfluidics for multiplexed label-free genomic studies

Gang L. Liu, Erik H. Anderson, J. Alex Liddle, Luke P. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We created a high-density nanorainbow sensor, which is Au nanowire array on a glass chip for label-free functional genomics. The physical mechanism of nanorainbow phenomena is due to the nanoscale size (i.e. width in this case) dependence of surface plasmon resonance. The integration of nanorainbow and nano- or microfluidic channel array allows developing label-free genomic and proteomic chip. Immobilization and hybridizations of less than 6.7 atto-mol 20bp complementary and mismatched oligonucleotides in multiplexed microfluidic channels are detected by monitoring the localized plasmon resonance shift of multiple detection sites on the Au nanorainbow simultaneously.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages788-790
Number of pages3
ISBN (Print)0974361119, 9780974361116
StatePublished - Jan 1 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period10/9/0510/13/05

Keywords

  • DNA hybridization
  • Microfluidics
  • Nanowires
  • Plasmon resonance

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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