TY - PAT
T1 - Nanopore-based system for trapping, controlled displacement, and sequencing of (bio)macromolecules
AU - Aksimentiev, Aleksei
AU - Dekker, Cornelis
N1 - STATEMENT AS TO FEDERALLY SPONSORED RESEARCH This invention was made with government support under HG007406 awarded by National Institutes of Health. The government has certain rights in the invention.
PY - 2022/5/17
Y1 - 2022/5/17
N2 - Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane having a first side and a second side, wherein the membrane has first and second pores disposed therein, a processing system; and a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations comprising: setting a first physical characteristic in a vicinity of the first pore to cause a first end of a molecule having the first end and a second end to be moved through the first pore; setting a second physical characteristic in a vicinity of the second pore to cause the second end of the molecule to be moved through the second pore; and adjusting the first physical characteristic to cause the molecule to be tightened, with a first given amount of force, between the first pore and the second pore. Additional embodiments are disclosed.
AB - Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane having a first side and a second side, wherein the membrane has first and second pores disposed therein, a processing system; and a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations comprising: setting a first physical characteristic in a vicinity of the first pore to cause a first end of a molecule having the first end and a second end to be moved through the first pore; setting a second physical characteristic in a vicinity of the second pore to cause the second end of the molecule to be moved through the second pore; and adjusting the first physical characteristic to cause the molecule to be tightened, with a first given amount of force, between the first pore and the second pore. Additional embodiments are disclosed.
M3 - Patent
M1 - 11333655
Y2 - 2017/09/06
ER -