Nanopore-based system for trapping, controlled displacement, and sequencing of (bio)macromolecules

Aleksei Aksimentiev (Inventor), Cornelis Dekker (Inventor)

Research output: Patent

Abstract

Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane having a first side and a second side, wherein the membrane has first and second pores disposed therein, a processing system; and a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations comprising: setting a first physical characteristic in a vicinity of the first pore to cause a first end of a molecule having the first end and a second end to be moved through the first pore; setting a second physical characteristic in a vicinity of the second pore to cause the second end of the molecule to be moved through the second pore; and adjusting the first physical characteristic to cause the molecule to be tightened, with a first given amount of force, between the first pore and the second pore. Additional embodiments are disclosed.
Original languageEnglish (US)
U.S. patent number11333655
Filing date9/6/17
StatePublished - May 17 2022

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