Nanoplasmonic monitoring of odorants binding to olfactory proteins from honeybee as biosensor for chemical detection

Diming Zhang; Yanli Lu; Qian Zhang; Yao Yao; Shuang Li; Hongliang Li; Shulin Zhuang; Jing Jiang; Gang Logan Liu; Qingjun Liu

doi:10.1016/j.snb.2015.06.091

Nanoplasmonic monitoring of odorants binding to olfactory proteins from honeybee as biosensor for chemical detection

Diming Zhang, Yanli Lu, Qian Zhang, Yao Yao, Shuang Li, Hongliang Li, Shulin Zhuang, Jing Jiang, Gang Logan Liu, Qingjun Liu

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract Odorant binding proteins (OBPs) are key soluble sensitive proteins for odor detections in animal olfactory systems. Here, we present a nanosensor based localized surface plasmon resonance (LSPR) to monitor binding of small odorant molecules to OBPs from honeybees. The binding of odorants molecules to OBPs, can be quantified by nanocup arrays from 10 nM to 1 mM, with a high refractive index sensing of LSPR wavelength shift in transmission spectra. Linear dose-dependent behavior can be observed in relationship of LSPR wavelength versus analyte concentrations. More than floral odorants, this type of bio-functionalized nanocups also showed potential applications in explosive detections for nitro-compounds such as 2,4,6-trinitrotoluene, 2,4-dinitrotoluene and 3-mononitrotoluene. This study demonstrated a LSPR device to monitor interactions between small molecules and proteins, which provided a great biosensor platform for healthcare diagnosis, environment monitoring and food analysis.

Original language	English (US)
Article number	18668
Pages (from-to)	341-349
Number of pages	9
Journal	Sensors and Actuators, B: Chemical
Volume	221
DOIs	https://doi.org/10.1016/j.snb.2015.06.091
State	Published - Jul 11 2015
Externally published	Yes

Keywords

Localized surface plasmon resonance (LSPR)
Nanocup arrays
Nitro-explosives
Odorant binding protein (OBP)
Small odorant molecules

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

Online availability

10.1016/j.snb.2015.06.091

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@article{685c45eca1f14c819991b63f71945e13,

title = "Nanoplasmonic monitoring of odorants binding to olfactory proteins from honeybee as biosensor for chemical detection",

abstract = "Abstract Odorant binding proteins (OBPs) are key soluble sensitive proteins for odor detections in animal olfactory systems. Here, we present a nanosensor based localized surface plasmon resonance (LSPR) to monitor binding of small odorant molecules to OBPs from honeybees. The binding of odorants molecules to OBPs, can be quantified by nanocup arrays from 10 nM to 1 mM, with a high refractive index sensing of LSPR wavelength shift in transmission spectra. Linear dose-dependent behavior can be observed in relationship of LSPR wavelength versus analyte concentrations. More than floral odorants, this type of bio-functionalized nanocups also showed potential applications in explosive detections for nitro-compounds such as 2,4,6-trinitrotoluene, 2,4-dinitrotoluene and 3-mononitrotoluene. This study demonstrated a LSPR device to monitor interactions between small molecules and proteins, which provided a great biosensor platform for healthcare diagnosis, environment monitoring and food analysis.",

keywords = "Localized surface plasmon resonance (LSPR), Nanocup arrays, Nitro-explosives, Odorant binding protein (OBP), Small odorant molecules",

author = "Diming Zhang and Yanli Lu and Qian Zhang and Yao Yao and Shuang Li and Hongliang Li and Shulin Zhuang and Jing Jiang and Liu, {Gang Logan} and Qingjun Liu",

note = "This work was supported by the National Natural Science Foundation of China (Grant No. 81371643 ; No. 31372254 ) and the Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars (Grant No. LR13H180002 ).",

year = "2015",

month = jul,

day = "11",

doi = "10.1016/j.snb.2015.06.091",

language = "English (US)",

volume = "221",

pages = "341--349",

journal = "Sensors and Actuators, B: Chemical",

issn = "0925-4005",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Nanoplasmonic monitoring of odorants binding to olfactory proteins from honeybee as biosensor for chemical detection

AU - Zhang, Diming

AU - Lu, Yanli

AU - Zhang, Qian

AU - Yao, Yao

AU - Li, Shuang

AU - Li, Hongliang

AU - Zhuang, Shulin

AU - Jiang, Jing

AU - Liu, Gang Logan

AU - Liu, Qingjun

N1 - This work was supported by the National Natural Science Foundation of China (Grant No. 81371643 ; No. 31372254 ) and the Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars (Grant No. LR13H180002 ).

PY - 2015/7/11

Y1 - 2015/7/11

N2 - Abstract Odorant binding proteins (OBPs) are key soluble sensitive proteins for odor detections in animal olfactory systems. Here, we present a nanosensor based localized surface plasmon resonance (LSPR) to monitor binding of small odorant molecules to OBPs from honeybees. The binding of odorants molecules to OBPs, can be quantified by nanocup arrays from 10 nM to 1 mM, with a high refractive index sensing of LSPR wavelength shift in transmission spectra. Linear dose-dependent behavior can be observed in relationship of LSPR wavelength versus analyte concentrations. More than floral odorants, this type of bio-functionalized nanocups also showed potential applications in explosive detections for nitro-compounds such as 2,4,6-trinitrotoluene, 2,4-dinitrotoluene and 3-mononitrotoluene. This study demonstrated a LSPR device to monitor interactions between small molecules and proteins, which provided a great biosensor platform for healthcare diagnosis, environment monitoring and food analysis.

AB - Abstract Odorant binding proteins (OBPs) are key soluble sensitive proteins for odor detections in animal olfactory systems. Here, we present a nanosensor based localized surface plasmon resonance (LSPR) to monitor binding of small odorant molecules to OBPs from honeybees. The binding of odorants molecules to OBPs, can be quantified by nanocup arrays from 10 nM to 1 mM, with a high refractive index sensing of LSPR wavelength shift in transmission spectra. Linear dose-dependent behavior can be observed in relationship of LSPR wavelength versus analyte concentrations. More than floral odorants, this type of bio-functionalized nanocups also showed potential applications in explosive detections for nitro-compounds such as 2,4,6-trinitrotoluene, 2,4-dinitrotoluene and 3-mononitrotoluene. This study demonstrated a LSPR device to monitor interactions between small molecules and proteins, which provided a great biosensor platform for healthcare diagnosis, environment monitoring and food analysis.

KW - Localized surface plasmon resonance (LSPR)

KW - Nanocup arrays

KW - Nitro-explosives

KW - Odorant binding protein (OBP)

KW - Small odorant molecules

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Nanoplasmonic monitoring of odorants binding to olfactory proteins from honeybee as biosensor for chemical detection

Abstract

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