Nanoparticle-nanocup hybrid array structure with a tunable sensitivity for colorimetric biosensing

Sujin Seo, Gang Logan Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Colorimetric detection is cost-effective and user-friendly when used for sensing target analytes without a need of bulky and expensive equipment. The extraordinary transmission phenomena through plasmonic periodic nanocup arrays achieve colorimetric sensing by detecting color changes of transmitted light associated with the refractive index variation. The application of the nanocup arrays, however, is relatively restricted due to a limited sensitivity for monolayered target analyte detections on the surface. In order to improve the sensitivity bounded by the underlying nanostructures, hybrid nanoparticle (NP)-nanocup array substrates are developed for enhancing the sensitivity to the refractive index change. The three dimensionally assembled Au NPs in circle along the sidewall of each nanocup increases the density of hot spots by the heterogeneous plasmonic coupling between the NP and the edge of the nanocup; thus a small refractive index change at the hot spot becomes easily detected than bare nanocup arrays. In addition to the bulk refractive index sensing, an ultrasensitive spectroscopic detection of the antigen-antibody binding is achieved by this three-dimensional self-assembly of Au NPs on the Au nanocup arrays.

Original languageEnglish (US)
Title of host publicationFrontiers in Biological Detection
Subtitle of host publicationFrom Nanosensors to Systems VIII
EditorsSharon M. Weiss, Amos Danielli, G. Logan Liu, Benjamin L. Miller, Brian T. Cunningham
PublisherSPIE
ISBN (Electronic)9781628419597
DOIs
StatePublished - Jan 1 2016
EventFrontiers in Biological Detection: From Nanosensors to Systems VIII - San Francisco, United States
Duration: Feb 14 2016Feb 15 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9725
ISSN (Print)1605-7422

Other

OtherFrontiers in Biological Detection: From Nanosensors to Systems VIII
CountryUnited States
CitySan Francisco
Period2/14/162/15/16

Keywords

  • nanocup arrays
  • plasmon
  • refractive index sensing
  • self-assembly

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Seo, S., & Liu, G. L. (2016). Nanoparticle-nanocup hybrid array structure with a tunable sensitivity for colorimetric biosensing. In S. M. Weiss, A. Danielli, G. L. Liu, B. L. Miller, & B. T. Cunningham (Eds.), Frontiers in Biological Detection: From Nanosensors to Systems VIII [97250D] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9725). SPIE. https://doi.org/10.1117/12.2211205