Nanomedicine strategies for molecular targets with MRI and optical imaging

Dipanjan Pan, Shelton D. Caruthers, Junjie Chen, Patrick M. Winter, Angana Senpan, Anne H. Schmieder, Samuel A. Wickline, Gregory M. Lanza

Research output: Contribution to journalReview article

Abstract

The science of 'theranostics plays a crucial role in personalized medicine, which represents the future of patient management. Over the last decade an increasing research effort has focused on the development of nanoparticle-based molecular-imaging and drug-delivery approaches, emerging as a multidisciplinary field that shows promise in understanding the components, processes, dynamics and therapies of a disease at a molecular level. The potential of nanometer-sized agents for early detection, diagnosis and personalized treatment of diseases is extraordinary. They have found applications in almost all clinically relevant biomedical imaging modality. In this review, a number of these approaches will be presented with a particular emphasis on MRI and optical imaging-based techniques. We have discussed both established molecular-imaging approaches and recently developed innovative strategies, highlighting the seminal studies and a number of successful examples of theranostic nanomedicine, especially in the areas of cardiovascular and cancer therapy.

Original languageEnglish (US)
Pages (from-to)471-490
Number of pages20
JournalFuture Medicinal Chemistry
Volume2
Issue number3
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

Fingerprint

Nanomedicine
Optical Imaging
Molecular Imaging
Precision Medicine
Nanoparticles
Early Diagnosis
Therapeutics
Research
Pharmaceutical Preparations
Neoplasms
Theranostic Nanomedicine

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Cite this

Pan, D., Caruthers, S. D., Chen, J., Winter, P. M., Senpan, A., Schmieder, A. H., ... Lanza, G. M. (2010). Nanomedicine strategies for molecular targets with MRI and optical imaging. Future Medicinal Chemistry, 2(3), 471-490. https://doi.org/10.4155/fmc.10.5

Nanomedicine strategies for molecular targets with MRI and optical imaging. / Pan, Dipanjan; Caruthers, Shelton D.; Chen, Junjie; Winter, Patrick M.; Senpan, Angana; Schmieder, Anne H.; Wickline, Samuel A.; Lanza, Gregory M.

In: Future Medicinal Chemistry, Vol. 2, No. 3, 01.03.2010, p. 471-490.

Research output: Contribution to journalReview article

Pan, D, Caruthers, SD, Chen, J, Winter, PM, Senpan, A, Schmieder, AH, Wickline, SA & Lanza, GM 2010, 'Nanomedicine strategies for molecular targets with MRI and optical imaging', Future Medicinal Chemistry, vol. 2, no. 3, pp. 471-490. https://doi.org/10.4155/fmc.10.5
Pan D, Caruthers SD, Chen J, Winter PM, Senpan A, Schmieder AH et al. Nanomedicine strategies for molecular targets with MRI and optical imaging. Future Medicinal Chemistry. 2010 Mar 1;2(3):471-490. https://doi.org/10.4155/fmc.10.5
Pan, Dipanjan ; Caruthers, Shelton D. ; Chen, Junjie ; Winter, Patrick M. ; Senpan, Angana ; Schmieder, Anne H. ; Wickline, Samuel A. ; Lanza, Gregory M. / Nanomedicine strategies for molecular targets with MRI and optical imaging. In: Future Medicinal Chemistry. 2010 ; Vol. 2, No. 3. pp. 471-490.
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