Nanomedicine Approaches Against Parasitic Worm Infections

Pengyang Li, Pamela E. Rios Coronado, Xóchitl R.R. Longstaff, Alexander J. Tarashansky, Bo Wang

Research output: Contribution to journalReview articlepeer-review

Abstract

Nanomedicine approaches have the potential to transform the battle against parasitic worm (helminth) infections, a major global health scourge from which billions are currently suffering. It is anticipated that the intersection of two currently disparate fields, nanomedicine and helminth biology, will constitute a new frontier in science and technology. This progress report surveys current innovations in these research fields and discusses research opportunities. In particular, the focus is on: (1) major challenges that helminth infections impose on mankind; (2) key aspects of helminth biology that inform future research directions; (3) efforts to construct nanodelivery platforms to target drugs and genes to helminths hidden in their hosts; (4) attempts in applying nanotechnology to enable vaccination against helminth infections; (5) outlooks in utilizing nanoparticles to enhance immunomodulatory activities of worm-derived factors to cure allergy and autoimmune diseases. In each section, achievements are summarized, limitations are explored, and future directions are assessed.

Original languageEnglish (US)
Article number1701494
JournalAdvanced Healthcare Materials
Volume7
Issue number13
DOIs
StatePublished - Jul 11 2018
Externally publishedYes

Keywords

  • drug delivery
  • immunomodulation
  • nanomedicine
  • parasites
  • vaccines

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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