Abstract
Various brain diseases including Alzheimer's disease, stroke, and cancer are major causes of death worldwide. Due to the notion that early diagnosis significantly increases success in treatments, several non-invasive bioimaging modalities such as MRI, CT, and PET are increasingly used to locate pathologic sites in the brain. To further enhance the quality of diagnostic imaging, efforts are incrementally made to couple imaging contrasts of interests to macromolecules or nanoparticles designed to cross over the brain-blood barrier and to bind to pathologic tissue. This chapter will therefore review such important emerging technologies for diagnostic imaging of brain and some preclinical and clinical success, so we can ultimately assist efforts to take diagnosis quality to the next level.
| Original language | English (US) |
|---|---|
| Title of host publication | Biomedical Engineering |
| Subtitle of host publication | Frontier Research and Converging Technologies |
| Publisher | Springer International Publishing |
| Pages | 77-89 |
| Number of pages | 13 |
| Volume | 9 |
| ISBN (Electronic) | 9783319218137 |
| ISBN (Print) | 9783319218120 |
| DOIs | |
| State | Published - Jul 23 2015 |
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Keywords
- Bioimaging
- Brain
- Brain-blood barrier
- Microfabrication
- Nanoparticle
ASJC Scopus subject areas
- Engineering(all)
- Medicine(all)
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Nanomaterials for diagnostic imaging of the brain. / Qin, Ellen; Kong, Hyunjoon.
Biomedical Engineering: Frontier Research and Converging Technologies. Vol. 9 Springer International Publishing, 2015. p. 77-89.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Nanomaterials for diagnostic imaging of the brain
AU - Qin, Ellen
AU - Kong, Hyunjoon
PY - 2015/7/23
Y1 - 2015/7/23
N2 - Various brain diseases including Alzheimer's disease, stroke, and cancer are major causes of death worldwide. Due to the notion that early diagnosis significantly increases success in treatments, several non-invasive bioimaging modalities such as MRI, CT, and PET are increasingly used to locate pathologic sites in the brain. To further enhance the quality of diagnostic imaging, efforts are incrementally made to couple imaging contrasts of interests to macromolecules or nanoparticles designed to cross over the brain-blood barrier and to bind to pathologic tissue. This chapter will therefore review such important emerging technologies for diagnostic imaging of brain and some preclinical and clinical success, so we can ultimately assist efforts to take diagnosis quality to the next level.
AB - Various brain diseases including Alzheimer's disease, stroke, and cancer are major causes of death worldwide. Due to the notion that early diagnosis significantly increases success in treatments, several non-invasive bioimaging modalities such as MRI, CT, and PET are increasingly used to locate pathologic sites in the brain. To further enhance the quality of diagnostic imaging, efforts are incrementally made to couple imaging contrasts of interests to macromolecules or nanoparticles designed to cross over the brain-blood barrier and to bind to pathologic tissue. This chapter will therefore review such important emerging technologies for diagnostic imaging of brain and some preclinical and clinical success, so we can ultimately assist efforts to take diagnosis quality to the next level.
KW - Bioimaging
KW - Brain
KW - Brain-blood barrier
KW - Microfabrication
KW - Nanoparticle
UR - http://www.scopus.com/inward/record.url?scp=84956779516&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84956779516&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-21813-7_4
DO - 10.1007/978-3-319-21813-7_4
M3 - Chapter
AN - SCOPUS:84956779516
SN - 9783319218120
VL - 9
SP - 77
EP - 89
BT - Biomedical Engineering
PB - Springer International Publishing
ER -