Abstract

Nanofluidic architectures and devices have already had a major impact on forefront problems in chemical analysis, especially those involving mass-limited samples. This critical review begins with a discussion of the fundamental flow physics that distinguishes nanoscale structures from their larger microscale analogs, especially the concentration polarization that develops at nanofluidic/microfluidic interfaces. Chemical manipulations in nanopores include nanopore-mediated separations, microsensors, especially resistive-pulse sensing of biomacromolecules, fluidic circuit analogs and single molecule measurements. Coupling nanofluidic structures to three-dimensional microfluidic networks is especially powerful and results in applications in sample preconcentration, nanofluidic injection/collection and fast diffusive mixing (160 references).

Original languageEnglish (US)
Pages (from-to)1060-1072
Number of pages13
JournalChemical Society Reviews
Volume39
Issue number3
DOIs
StatePublished - Mar 1 2010

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Nanofluidics
Nanopores
Chemical analysis
Microfluidics
Microsensors
Fluidics
Physics
Polarization
Molecules
Networks (circuits)

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Nanofluidics in chemical analysis. / Piruska, Aigars; Gong, Maojun; Sweedler, Jonathan V; Bohn, Paul W.

In: Chemical Society Reviews, Vol. 39, No. 3, 01.03.2010, p. 1060-1072.

Research output: Contribution to journalReview article

Piruska, A, Gong, M, Sweedler, JV & Bohn, PW 2010, 'Nanofluidics in chemical analysis', Chemical Society Reviews, vol. 39, no. 3, pp. 1060-1072. https://doi.org/10.1039/b900409m
Piruska, Aigars ; Gong, Maojun ; Sweedler, Jonathan V ; Bohn, Paul W. / Nanofluidics in chemical analysis. In: Chemical Society Reviews. 2010 ; Vol. 39, No. 3. pp. 1060-1072.
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