Abstract
Nanofluidic architectures and devices have already had a major impact on forefront problems in chemical analysis, especially those involving mass-limited samples. This critical review begins with a discussion of the fundamental flow physics that distinguishes nanoscale structures from their larger microscale analogs, especially the concentration polarization that develops at nanofluidic/microfluidic interfaces. Chemical manipulations in nanopores include nanopore-mediated separations, microsensors, especially resistive-pulse sensing of biomacromolecules, fluidic circuit analogs and single molecule measurements. Coupling nanofluidic structures to three-dimensional microfluidic networks is especially powerful and results in applications in sample preconcentration, nanofluidic injection/collection and fast diffusive mixing (160 references).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1060-1072 |
| Number of pages | 13 |
| Journal | Chemical Society Reviews |
| Volume | 39 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2010 |
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ASJC Scopus subject areas
- Chemistry(all)
Cite this
Nanofluidics in chemical analysis. / Piruska, Aigars; Gong, Maojun; Sweedler, Jonathan V; Bohn, Paul W.
In: Chemical Society Reviews, Vol. 39, No. 3, 01.03.2010, p. 1060-1072.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Nanofluidics in chemical analysis
AU - Piruska, Aigars
AU - Gong, Maojun
AU - Sweedler, Jonathan V
AU - Bohn, Paul W.
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Nanofluidic architectures and devices have already had a major impact on forefront problems in chemical analysis, especially those involving mass-limited samples. This critical review begins with a discussion of the fundamental flow physics that distinguishes nanoscale structures from their larger microscale analogs, especially the concentration polarization that develops at nanofluidic/microfluidic interfaces. Chemical manipulations in nanopores include nanopore-mediated separations, microsensors, especially resistive-pulse sensing of biomacromolecules, fluidic circuit analogs and single molecule measurements. Coupling nanofluidic structures to three-dimensional microfluidic networks is especially powerful and results in applications in sample preconcentration, nanofluidic injection/collection and fast diffusive mixing (160 references).
AB - Nanofluidic architectures and devices have already had a major impact on forefront problems in chemical analysis, especially those involving mass-limited samples. This critical review begins with a discussion of the fundamental flow physics that distinguishes nanoscale structures from their larger microscale analogs, especially the concentration polarization that develops at nanofluidic/microfluidic interfaces. Chemical manipulations in nanopores include nanopore-mediated separations, microsensors, especially resistive-pulse sensing of biomacromolecules, fluidic circuit analogs and single molecule measurements. Coupling nanofluidic structures to three-dimensional microfluidic networks is especially powerful and results in applications in sample preconcentration, nanofluidic injection/collection and fast diffusive mixing (160 references).
UR - http://www.scopus.com/inward/record.url?scp=77955798929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955798929&partnerID=8YFLogxK
U2 - 10.1039/b900409m
DO - 10.1039/b900409m
M3 - Review article
C2 - 20179825
AN - SCOPUS:77955798929
VL - 39
SP - 1060
EP - 1072
JO - Chemical Society Reviews
JF - Chemical Society Reviews
SN - 0306-0012
IS - 3
ER -