Nanofabricated plasmonic nano-bio hybrid structures in biomedical detection

Wenwei Zheng, Heather C. Chiamori, Gang Logan Liu, Liwei Lin, Fanqing Frank Chen

Research output: Contribution to journalArticlepeer-review


Our study of biological systems increasingly depends on our ability to dynamically and quantitatively measure the molecular processes with high sensitivity, speed, flexibility, multi-plexity, throughput, and reproducibility, usually within the context of a complex biological and chemical mixture of tiny amount. To address these major challenges, plasmon-resonant nanostructure biomolecule hybrids (nano-bio hybrids), so-called plasmonic nanobiosensors, are being developed and viewed as one key breakthrough area for real-time and parallelized biomedical analysis with high sensitivity and selectivity. Hereby, we present a solution of integrated plasmonic system by synergizing three core techniques: (i) nanoplasmonics that manipulates electromagnetic radiation (light) at dielectric-metal interfaces by tuning properties of nanomaterials, (ii) nanofabrication and controlled synthesis of nanomaterials containing noble metals (e.g., Au, Ag, Pt, and Cu), and (iii) bioconjugates techniques that modify surface of nanomaterials with various bioprobes (e.g., antibodies, enzymes, aptamers, and molecular imprint polymers). Applications of these plasmonic nano-bio hybrid structures are also discussed.

Original languageEnglish (US)
Pages (from-to)213-233
Number of pages21
JournalNanotechnology Reviews
Issue number3
StatePublished - Jun 1 2012


  • Genomic sensing
  • Localized surface plasmon spectroscopy (LSPR)
  • Nano-bio hybrids
  • Plasmonic nano-resonance
  • Plasmonic structures
  • Proteomic sensing
  • Surface enhancements
  • Surface plasmons
  • Surface-enhanced Raman spectroscopy (SERS)

ASJC Scopus subject areas

  • Biotechnology
  • Medicine (miscellaneous)
  • Materials Science (miscellaneous)
  • Energy Engineering and Power Technology
  • Engineering (miscellaneous)
  • Process Chemistry and Technology


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