@article{814df969a3a64ea7842c8cf311632f8a,
title = "Nanodiscs in Membrane Biochemistry and Biophysics",
abstract = "Membrane proteins play a most important part in metabolism, signaling, cell motility, transport, development, and many other biochemical and biophysical processes which constitute fundamentals of life on the molecular level. Detailed understanding of these processes is necessary for the progress of life sciences and biomedical applications. Nanodiscs provide a new and powerful tool for a broad spectrum of biochemical and biophysical studies of membrane proteins and are commonly acknowledged as an optimal membrane mimetic system that provides control over size, composition, and specific functional modifications on the nanometer scale. In this review we attempted to combine a comprehensive list of various applications of nanodisc technology with systematic analysis of the most attractive features of this system and advantages provided by nanodiscs for structural and mechanistic studies of membrane proteins.",
author = "Denisov, {Ilia G.} and Sligar, {Stephen G.}",
note = "Funding Information: Discovery and development of the nanodisc technology and applications in the Sligar laboratory was accomplished by a plethora of individuals including: Timothy Bayburt, Joe Carlson, Yelena Grinkova, Mark McLean, Aditi Das, Steve Grimme, Natanya Civjan, Bradley Baas, Aleksandra Kijac, Andrew Leitz, Andrew Shaw, Amy Shih, Stephanie Gantt, Yogan Khatri, Daniel Frank, Catherine Baker, Michael Marty, Abhinav Luthra, Michael Gregory, Ivan Lenov, Xin Ye, and Ruchia Duggal. Collaborations over the years have enabled newavenues of exploration. These have included Ana Jonas (UIUC), Barry Springer (Johnson&Johnson Pharmaceuticals), James Morrissey (UIUC), Chad Rienstra (UIUC), Mary Schuler (UIUC), Klaus Schulten (UIUC), Emad Tajkhorshid (UIUC), Ryan Bailey (UIUC), Robert Gennis (UIUC), William Atkins (University of Washington), James Kincaid and Piotr Mak (Marquette University), Richard Van Duyne, George Schatz, Vinayak Dravid, Chang Liu (Northwestern University), Vsevolod Gurevich (Vanderbilt University), Mark Ginsberg (UCSD), Lisa Arleth and Birger Lindberg Moller (University of Copenhagen), Milan Mrksich (Northwestern University), Michael Gross (Washington University in Saint-Louis), Frank Duong (University of British Columbia), Dennis Voelker (National Jewish Health Center), William Klein (Northwestern University), Dan Oprian (Brandeis University), Tom Laue (University of New Hampshire), Gerald Hazelbauer (University of Missouri-Columbia), Phil Dawson (Scripps Research Institute), Tom Meade (Northwestern University), Tom Poulos (UC Irvine), John Dawson (University of South Carolina), and Brian Hoffman (Northwestern University) together with their many talented students and researchers in their laboratories. We want to especially acknowledge the Frederick National Laboratory for Cancer Research led by Dave Heimbrook and the Ras collaborations led by Andy Stephen. Research in the Sligar laboratory has been supported for the past 40 years by grants from the National Institutes of Health, including NIH GM33775, GM31756, GM110428, and GM118145. We want to especially acknowledge receipt of an NIGMS MIRA award that is allowing us to fully explore the opportunities for fundamental discovery in the application of nanodiscs to human health issues. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = mar,
day = "22",
doi = "10.1021/acs.chemrev.6b00690",
language = "English (US)",
volume = "117",
pages = "4669--4713",
journal = "Chemical Reviews",
issn = "0009-2665",
publisher = "American Chemical Society",
number = "6",
}