Nanodiscs for structural and functional studies of membrane proteins

Ilia G. Denisov, Stephen G. Sligar

Research output: Contribution to journalReview articlepeer-review


Membrane proteins have long presented a challenge to biochemical and functional studies. In the absence of a bilayer environment, individual proteins and critical macromolecular complexes may be insoluble and may display altered or absent activities. Nanodisc technology provides important advantages for the isolation, purification, structural resolution and functional characterization of membrane proteins. In addition, the ability to precisely control the nanodisc composition provides a nanoscale membrane surface for investigating molecular recognition events.

Original languageEnglish (US)
Pages (from-to)481-486
Number of pages6
JournalNature Structural and Molecular Biology
Issue number6
StatePublished - Jun 7 2016

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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