Nanoceramics intercalated with Gd-DTPA for potential imaging of systems in VIVO

Seo Young Kwak, Waltraud M. Kriven, Robert B. Clarkso, Benjamin J. Tucker, R. Linn Belford

Research output: Contribution to journalConference articlepeer-review

Abstract

Nano-sized ceramic particles, such as layered double hydroxides (LDHs) have been developed to preserve and deliver drugs or genes in the body. In this report, we describe a new ceramic contrast reagent for magnetic resonance imaging (MRI). It has been developed by intercalation of the chelate diethylenetriamine-N, N, N', N", N"-pentaacetate (DTPA) complexed with Gd3+ (Gd-DTPA). Its characteristic electron paramagnetic resonance (EPR) spectrum shows a slow tumbling, space-limited environment in the LDH matrix. Gd-DTPA LDH is designed to track the route of an intercalated drug and to be applied as a new nanoceramic contrast reagent for MRI in order to detect any image tumors and their dendrites. According to XRD, SEM and TEM, the nanohybrid crystal structure and morphology possess typical, two-dimensional metal ion layering. Elemental analysis (CHN and ICP) shows a stable Gd-DTPA complex in the interlayers of LDH. This idea has the potential to extend the use of nanoceramics for gene or drug delivery.

Original languageEnglish (US)
Pages (from-to)55-62
Number of pages8
JournalCeramic Engineering and Science Proceedings
Volume26
Issue number6
StatePublished - Dec 1 2005
Event29th International Conference on Advanced Ceramics and Composites - Cocoa Beach, FL, United States
Duration: Jan 23 2005Jan 28 2005

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

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