Nano-encrypted morse code: A versatile approach to programmable and reversible nanoscale assembly and disassembly

Ngo Yin Wong, Hang Xing, Li Huey Tan, Yi Lu

Research output: Contribution to journalArticlepeer-review

Abstract

While much work has been devoted to nanoscale assembly of functional materials, selective reversible assembly of components in the nanoscale pattern at selective sites has received much less attention. Exerting such a reversible control of the assembly process will make it possible to fine-tune the functional properties of the assembly and to realize more complex designs. Herein, by taking advantage of different binding affinities of biotin and desthiobiotin toward streptavidin, we demonstrate selective and reversible decoration of DNA origami tiles with streptavidin, including revealing an encrypted Morse code "NANO" and reversible exchange of uppercase letter "I" with lowercase "i". The yields of the conjugations are high (>90%), and the process is reversible. We expect this versatile conjugation technique to be widely applicable with different nanomaterials and templates.

Original languageEnglish (US)
Pages (from-to)2931-2934
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number8
DOIs
StatePublished - Feb 27 2013

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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