Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Immunology and Microbiology

• Antineoplastic Activity 100%
• Interleukin-15 Receptor 100%
• Interleukin 15 100%
• Myxoma Virus 100%
• Mouse 60%
• Natural Killer Cell 60%
• Leporidae 60%
• Cytokine 40%
• Infectious Agent 20%
• Intravenous Immunoglobulin 20%
• T Cell 20%
• Cancer Cell 20%
• Cell Line 20%
• C57BL 6 Mouse 20%
• Cytotoxic T-Cell 20%
• Components of the Immune System 20%
• Murine 20%
• Viral Vector 20%
• Rabbitpox Virus 20%

Keyphrases

• Fusion Protein 100%
• Enhanced Antitumor Activity 100%
• Interleukin-15 Receptor alpha 100%
• Interleukin-15 (IL-15) 100%
• Myxoma Virus 100%
• Natural Killer Cells 16%
• Tumor 11%
• In Vivo Experiment 11%
• Virus 5%
• Recombinant 5%
• Cancer Cells 5%
• C57BL 5%
• Infiltration 5%
• Kidney 5%
• Tumor Growth 5%
• T Cells 5%
• Therapeutic Agents 5%
• Fluorescent Reporter 5%
• CD8+ T Cells 5%
• Subcutaneous Tumor 5%
• Adaptive Components 5%
• Growth Curve 5%
• Functional Activity 5%
• Co-expression 5%
• Antitumor 5%
• RAG1 5%
• B16F10 5%
• Prolonged Survival 5%
• Immunosuppressive Cytokines 5%
• Multistep Growth 5%
• Murine Melanoma 5%
• CTLL-2 Cells 5%
• Survival Benefit 5%
• Melanoma B16 5%
• Poxvirus 5%
• Red Fluorescent 5%
• Components of the Immune System 5%
• TdTomato 5%
• Virus Vector 5%