TY - JOUR
T1 - Myocardial and Pancreatic Lesions Induced by T-2 Toxin, a Trichothecene Mycotoxin, in Swine
AU - Pang, V. F.
AU - Adams, J. H.
AU - Beasley, V. R.
AU - Buck, W. B.
AU - Haschek, W. M.
N1 - Funding Information:
Authors thank Mr. R. K. Manuel for technical assistance, Mr. D. H. Fritts for assistance with photomicrography, and Mr. Steve Swanson for T-2 toxin. Facilities provided by the Center for Electron Microscopy, School of Life Sciences, and Electron Microscopy Laboratory, College of Veterinary Medicine, University of Illinois. Supported by the US Army Medical Research and Development Command, Contract No. DAMD 17-82-C-2179.
PY - 1986/5
Y1 - 1986/5
N2 - Myocardial and pancreatic lesions induced by sublethal doses of T-2 toxin in swine were characterized by light and electron microscopy. Toxin was given intravenously to six 17- to 18-week-old pigs. Pigs were killed 24 or 48 hours after treatment. Grossly, subendocardial hemorrhages, multifocal pinpoint white foci in myocardium, and pancreatic edema occurred in one treated pig. Histologic changes in myocardium of treated pigs consisted of multifocal edema, mononuclear cell infiltration, myofiber hyalinization, vacuolation, and contraction bands with nuclear pyknosis. Ultrastructurally, there were areas of edema, myofibrillar disorganization, dilation of sarcoplasmic reticulum, and formation of hypercontraction bands. Myocardial mineralization was seen in the pig with gross lesions. Pancreatic changes in treated pigs consisted of multifocal acinar degeneration and necrosis. Ultrastructural changes included irregular dilation of rough endoplasmic reticulum and abnormal zymogen granules. Thus, in addition to radiomimetic lesions of the gastrointestinal tract and lymphoid organs, heart and pancreas are target organs of T-2 toxin in swine.
AB - Myocardial and pancreatic lesions induced by sublethal doses of T-2 toxin in swine were characterized by light and electron microscopy. Toxin was given intravenously to six 17- to 18-week-old pigs. Pigs were killed 24 or 48 hours after treatment. Grossly, subendocardial hemorrhages, multifocal pinpoint white foci in myocardium, and pancreatic edema occurred in one treated pig. Histologic changes in myocardium of treated pigs consisted of multifocal edema, mononuclear cell infiltration, myofiber hyalinization, vacuolation, and contraction bands with nuclear pyknosis. Ultrastructurally, there were areas of edema, myofibrillar disorganization, dilation of sarcoplasmic reticulum, and formation of hypercontraction bands. Myocardial mineralization was seen in the pig with gross lesions. Pancreatic changes in treated pigs consisted of multifocal acinar degeneration and necrosis. Ultrastructural changes included irregular dilation of rough endoplasmic reticulum and abnormal zymogen granules. Thus, in addition to radiomimetic lesions of the gastrointestinal tract and lymphoid organs, heart and pancreas are target organs of T-2 toxin in swine.
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U2 - 10.1177/030098588602300312
DO - 10.1177/030098588602300312
M3 - Article
C2 - 3727316
AN - SCOPUS:0022897875
SN - 0300-9858
VL - 23
SP - 310
EP - 319
JO - Veterinary pathology
JF - Veterinary pathology
IS - 3
ER -