Mycobacterium tuberculosis phagosome

V. Deretic, R. A. Fratti

Research output: Contribution to journalReview article

Abstract

The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment-specialized regulators of vesicular trafficking and other parts of membrane fusion machinery are likely to play a role in these processes. Here we summarize the emerging view of mycobacterial phagosome maturation arrest in the context of the dynamic processes of intracellular membrane trafficking.

Original languageEnglish (US)
Pages (from-to)1603-1609
Number of pages7
JournalMolecular Microbiology
Volume31
Issue number6
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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