Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest

Rutilio A. Fratti, Jennifer Chua, Isabelle Vergne, Vojo Deretic

Research output: Contribution to journalArticlepeer-review


The tubercle bacillus parasitizes macrophages by inhibiting phagosome maturation into the phagolysosome. This phenomenon underlies the tuberculosis pandemic involving 2 billion people. We report here how Mycobacterium tuberculosis causes phagosome maturation arrest. A glycosylated M. tuberculosis phosphatidylinositol [mannose-capped lipoarabinomannan (ManLAM)] interfered with the phagosomal acquisition of the lysosomal cargo and syntaxin 6 from the trans-Golgi network. ManLAM specifically inhibited the pathway dependent on phosphatidylinositol 3-kinase activity and phosphatidylinositol 3-phosphate-binding effectors. These findings identify ManLAM as the M. tuberculosis product responsible for the inhibition of phagosomal maturation.

Original languageEnglish (US)
Pages (from-to)5437-5442
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number9
StatePublished - Apr 29 2003
Externally publishedYes

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest'. Together they form a unique fingerprint.

Cite this