Mutants of Escherichia coli with temperature-sensitive lesions in membrane phospholipid synthesis: Genetic analysis of glycerol-3-phosphate acyltransferase mutants

John E Cronan, G. Nigel Godson

Research output: Contribution to journalArticle


Escherichia coli mutants possessing temperature-sensitive lesions in glycerol-3-phosphate acyltransferase, the enzyme catalysing the first step in phospholipid biosynthesis, have been characterized genetically. By recombinational and complementation tests, the mutants have been found to map in a single locus, called plsA, which is cotransducibile with the purE locus and lies between the purE and proC loci at minute 13 on the E. coli genetic map.

Original languageEnglish (US)
Pages (from-to)199-210
Number of pages12
JournalMGG Molecular & General Genetics
Issue number3
StatePublished - Sep 1 1972
Externally publishedYes


ASJC Scopus subject areas

  • Genetics

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