Multistep one-pot reactions combining biocatalysts and chemical catalysts for asymmetric synthesis

Carl A. Denard, John F. Hartwig, Huimin Zhao

Research output: Contribution to journalReview article

Abstract

In a continuous effort to emulate the efficiency of biosynthetic pathways, considerable progress has been made in developing one-pot chemoenzymatic processes that take full advantage of the chemo-, regio-, and stereoselectivity of biocatalysts and the productivity of chemical catalysts. Over the last 20 years, research in this area has provided us with proof of concept examples in which chemical and biological transformations occur in one vessel, sequentially or concurrently. These transformations typically access products with high enantiopurity and chemical diversity. In this perspective, we present some of the most successful reports in this field.

Original languageEnglish (US)
Pages (from-to)2856-2864
Number of pages9
JournalACS Catalysis
Volume3
Issue number12
DOIs
StatePublished - Dec 6 2013

Fingerprint

Biocatalysts
Catalysts
Enzymes
Stereoselectivity
Regioselectivity
Productivity

Keywords

  • artificial metalloenzyme
  • biocatalysis
  • chemoenzymatic
  • dynamic kinetic resolution
  • supramolecular assembly
  • tandem catalysis

ASJC Scopus subject areas

  • Catalysis

Cite this

Multistep one-pot reactions combining biocatalysts and chemical catalysts for asymmetric synthesis. / Denard, Carl A.; Hartwig, John F.; Zhao, Huimin.

In: ACS Catalysis, Vol. 3, No. 12, 06.12.2013, p. 2856-2864.

Research output: Contribution to journalReview article

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