Multiplexed NMR: An automated CapNMR dual-sample probe

James A. Norcross, Craig T. Milling, Dean L. Olson, Duanxiang Xu, Anthony Audrieth, Robert Albrecht, Ke Ruan, John Likos, Claude Jones, Timothy L. Peck

Research output: Contribution to journalArticle

Abstract

A new generation of microscale, nuclear magnetic resonance (CapNMR) probe technology employs two independent detection elements to accommodate two samples simultaneously. Each detection element in the dual-sample CapNMR probe (DSP) delivers the same spectral resolution and S/N as in a CapNMR probe configured to accommodate one sample at a time. A high degree of electrical isolation allows the DSP to be used in a variety of data acquisition modes. Both samples are shimmed simultaneously to achieve high spectral resolution for simultaneous data acquisition, or alternatively, a flowcell-specific shim set is readily called via spectrometer subroutines to enable acquisition from one sample while the other is being loaded. An automation system accommodates loading of two samples via dual injection ports on an autosampler and two completely independent flowpaths leading to dedicated flowcells in the DSP probe.

Original languageEnglish (US)
Pages (from-to)7227-7236
Number of pages10
JournalAnalytical chemistry
Volume82
Issue number17
DOIs
StatePublished - Sep 1 2010

ASJC Scopus subject areas

  • Analytical Chemistry

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  • Cite this

    Norcross, J. A., Milling, C. T., Olson, D. L., Xu, D., Audrieth, A., Albrecht, R., Ruan, K., Likos, J., Jones, C., & Peck, T. L. (2010). Multiplexed NMR: An automated CapNMR dual-sample probe. Analytical chemistry, 82(17), 7227-7236. https://doi.org/10.1021/ac101003f