Multiplexed cytokine detection for immunodiagnostics using silicon photonic microring resonator arrays

Heather M. Robison, Patricio Escalante, Enrique Valera, Courtney L. Erskine, Loretta Auvil, Humberto C. Sasieta, Colleen Bushell, Michael Welge, Ryan C. Bailey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Latent tuberculosis infection (LTBI) is estimated in one third of the world with 10% proceeding to active tuberculosis (TB). Current diagnostics cannot definitively identify LTBI and assess reactivation risk. We introduce a precision medicine-based approach to LTBI diagnostics that leverages a high-throughput, multiplexed cytokine detection technology and machine learning bioinformatics to reveal LTBI signatures for risk stratification. Cytokines secreted from antigen-challenged peripheral blood mononuclear cells were detected using silicon photonic sensor arrays and multidimensional data correlation of individually-normalized immune responses revealed diagnostic signatures predictive for LTBI status. These results may improve the positive prediction of LTBI status and reactivation risk.

Original languageEnglish (US)
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages3-4
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - Jan 1 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: Oct 22 2017Oct 26 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period10/22/1710/26/17

Keywords

  • Feature Selection
  • Immunoassay
  • Latent Tuberculosis
  • Microring Resonators

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Fingerprint Dive into the research topics of 'Multiplexed cytokine detection for immunodiagnostics using silicon photonic microring resonator arrays'. Together they form a unique fingerprint.

  • Cite this

    Robison, H. M., Escalante, P., Valera, E., Erskine, C. L., Auvil, L., Sasieta, H. C., Bushell, C., Welge, M., & Bailey, R. C. (2020). Multiplexed cytokine detection for immunodiagnostics using silicon photonic microring resonator arrays. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 3-4). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.