Multiple Running Speed Signals in Medial Entorhinal Cortex

James R. Hinman, Mark P. Brandon, Jason R. Climer, G. William Chapman, Michael E. Hasselmo

Research output: Contribution to journalArticlepeer-review

Abstract

Grid cells in medial entorhinal cortex (MEC) can be modeled using oscillatory interference or attractor dynamic mechanisms that perform path integration, a computation requiring information about running direction and speed. The two classes of computational models often use either an oscillatory frequency or a firing rate that increases as a function of running speed. Yet it is currently not known whether these are two manifestations of the same speed signal or dissociable signals with potentially different anatomical substrates. We examined coding of running speed in MEC and identified these two speed signals to be independent of each other within individual neurons. The medial septum (MS) is strongly linked to locomotor behavior, and removal of MS input resulted in strengthening of the firing rate speed signal, while decreasing the strength of the oscillatory speed signal. Thus, two speed signals are present in MEC that are differentially affected by disrupted MS input.

Original languageEnglish (US)
Pages (from-to)666-679
Number of pages14
JournalNeuron
Volume91
Issue number3
DOIs
StatePublished - Aug 3 2016
Externally publishedYes

Keywords

  • entorhinal cortex
  • grid cell
  • medial septum
  • path integration
  • theta rhythm

ASJC Scopus subject areas

  • General Neuroscience

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