TY - JOUR
T1 - Multiple reassortment between pandemic (H1N1) 2009 and endemic influenza viruses in pigs, United States
AU - Ducatez, Mariette F.
AU - Hause, Ben
AU - Stigger-Rosser, Evelyn
AU - Darnell, Daniel
AU - Corzo, Cesar
AU - Juleen, Kevin
AU - Simonson, Randy
AU - Brockwell-Staats, Christy
AU - Rubrum, Adam
AU - Wang, David
AU - Webb, Ashley
AU - Crumpton, Jeri Carol
AU - Lowe, James
AU - Gramer, Marie
AU - Webby, Richard J.
PY - 2011/9
Y1 - 2011/9
N2 - As a result of human-to-pig transmission, pandemic influenza A (H1N1) 2009 virus was detected in pigs soon after it emerged in humans. In the United States, this transmission was quickly followed by multiple reassortment between the pandemic virus and endemic swine viruses. Nine reassortant viruses representing 7 genotypes were detected in commercial pig farms in the United States. Field observations suggested that the newly described reassortant viruses did not differ substantially from pandemic (H1N1) 2009 or endemic strains in their ability to cause disease. Comparable growth properties of reassortant and endemic viruses in vitro supported these observations; similarly, a representative reassortant virus replicated in ferrets to the same extent as did pandemic (H1N1) 2009 and endemic swine virus. These novel reassortant viruses highlight the increasing complexity of influenza viruses within pig populations and the frequency at which viral diversifi cation occurs in this ecologically important viral reservoir.
AB - As a result of human-to-pig transmission, pandemic influenza A (H1N1) 2009 virus was detected in pigs soon after it emerged in humans. In the United States, this transmission was quickly followed by multiple reassortment between the pandemic virus and endemic swine viruses. Nine reassortant viruses representing 7 genotypes were detected in commercial pig farms in the United States. Field observations suggested that the newly described reassortant viruses did not differ substantially from pandemic (H1N1) 2009 or endemic strains in their ability to cause disease. Comparable growth properties of reassortant and endemic viruses in vitro supported these observations; similarly, a representative reassortant virus replicated in ferrets to the same extent as did pandemic (H1N1) 2009 and endemic swine virus. These novel reassortant viruses highlight the increasing complexity of influenza viruses within pig populations and the frequency at which viral diversifi cation occurs in this ecologically important viral reservoir.
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U2 - 10.3201/1709.110338
DO - 10.3201/1709.110338
M3 - Article
C2 - 21892996
AN - SCOPUS:80052151455
SN - 1080-6040
VL - 17
SP - 1624
EP - 1629
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 9
ER -