Multiple pinhole aperture design using a modified uniform cramer-rao bound

L. J. Meng, N. H. Clinthorne

Research output: Contribution to journalConference articlepeer-review


This paper presents a design study of using multiple pinhole apertures in small animal SPECT imaging applications. The SPECT system is based on the use of an existing ADAC gamma camera. For quantifying the performance of a detector design, we used the minimum achievable variance at several locations in the images, given some constraints on the resulting spatial resolution. This approach was formerly proposed as the Uniform Cramer-Rao bound (UCRB). In this work, we propose to use a resolution constraint that is imposed on the mean gradient vector. This partially overcomes the limitations of the former UCRB approach based on the bias-gradient norm constraint. We applied this method for studying the effect of design parameters, such as number of pinholes and pinhole size, on the performance of the detector system.

Original languageEnglish (US)
Article numberM7-45
Pages (from-to)2305-2309
Number of pages5
JournalIEEE Nuclear Science Symposium Conference Record
StatePublished - Dec 1 2003
Externally publishedYes
Event2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference - Portland, OR, United States
Duration: Oct 19 2003Oct 25 2003


  • Multiple Pinhole
  • UCRB
  • Variance-resolution tradeoffs

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging


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