Multimodal imaging and theranostic application of disease-directed agents

Joseph Caffarini, Nathan Kelleher, Christian C. Konopka, Madeline Mazurek, Anuradha Nandyala, Dwani Patel, Stephanie Slania, Sheryl Wang, Ravi Chandra Yada, Dipanjan Pan

Research output: Contribution to journalArticle

Abstract

Contrast agents have long helped researchers and physicians alike delineate boundaries, but new diagnostic information is always sought after. A new field of molecularly targeted CT agents hopes to fill this void and supply physicians with prognostic information to find better treatments for patients. Borrowing from drug delivery and design, nanoparticles and similar platforms are being explored to help visualize complex biologic processes with never before seen resolution and fidelity. We discuss the development of this field and feasibility of translating some of these prospects to the clinic. Advances in chemistry, molecular biology, and engineering have molded this field emphasizing the early detection and treatment of diseases at the molecular and cellular level. Myriads of nanomedicine platforms have been proposed and developed and tested in laboratories and in preclinical models. However, very few have been translated to clinical trials. It is therefore a critical issue to recognize the factors affecting their eventual application in human. Better understanding of biological and biophysical obstacles encountered by these agents is necessary. Toward this aim, we critically review our present understanding of the biological obstacles encountered by the nano-agents, which we hope will motivate more studies to tune these technologies for future translational and clinical applications.

Original languageEnglish (US)
Pages (from-to)75-104
Number of pages30
JournalTopics in Medicinal Chemistry
Volume20
DOIs
StatePublished - Jun 1 2016

Keywords

  • Molecular imaging
  • Multimodal imaging
  • Theranostics
  • Therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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  • Cite this

    Caffarini, J., Kelleher, N., Konopka, C. C., Mazurek, M., Nandyala, A., Patel, D., Slania, S., Wang, S., Yada, R. C., & Pan, D. (2016). Multimodal imaging and theranostic application of disease-directed agents. Topics in Medicinal Chemistry, 20, 75-104. https://doi.org/10.1007/7355_2015_91