Multidimensional ADHD Symptom Profiles: Associations with Adverse Childhood Experiences

Adverse childhood experiences (ACEs) are associated with a range of negative health outcomes, including attention-deficit/hyperactivity disorder (ADHD) and neurocognitive deficits. This study identified symptom profiles in adult patients undergoing neuropsychological evaluations for ADHD and examined the association between these profiles and ACEs.Utilizing unsupervised machine learning models, the study analyzed data from 208 adult patients.The Gaussian Mixture Model revealed two distinct symptom profiles: “Severely Impaired” and “Moderately Impaired”. The “Severely Impaired” profile, 23.6\ was characterized by more severe ADHD symptomatology in childhood and worse neurocognitive performance. The “Moderately Impaired” profile, 76.4\ had scores in the average range for self-reported internalizing and externalizing psychopathology and better neurocognitive performance. There was a greater number of ACEs reported by patients in the Severely Impaired profile than the Moderately Impaired profile (p = .022). Specifically, using an ACEs cutoff of ≥4, 53.1\ compared with 34.6\p = .020). Profiles were not related to clinician-ascribed diagnosis.Findings underscore the association between ACEs and worse symptom profiles marked by impaired neurocognitive function, increased internalizing and externalizing psychopathology, and heightened perceived stress in adults with ADHD. Future research may explore the effect of ACEs on symptom profiles in diverse populations and potential moderators or mediators of these associations. Findings offers valuable insights for clinicians in their assessment and treatment planning.