Multicolor quantum dots for molecular diagnostics of cancer

Andrew M. Smith; Shivang Dave; Shuming Nie; Lawrence True; Xiaohu Gao

doi:10.1586/14737159.6.2.231

Multicolor quantum dots for molecular diagnostics of cancer

Andrew M. Smith, Shivang Dave, Shuming Nie, Lawrence True, Xiaohu Gao

Research output: Contribution to journal › Review article › peer-review

Abstract

In the pursuit of sensitive and quantitative methods to detect and diagnose cancer, nanotechnology has been identified as a field of great promise. Semiconductor quantum dots are nanoparticles with intense, stable fluorescence, and could enable the detection of tens to hundreds of cancer biomarkers in blood assays, on cancer tissue biopsies, or as contrast agents for medical imaging. With the emergence of gene and protein profiling and microarray technology, high-throughput screening of biomarkers has generated databases of genomic and expression data for certain cancer types, and has identified new cancer-specific markers. Quantum dots have the potential to expand this in vitro analysis, and extend it to cellular, tissue and whole-body multiplexed cancer biomarker imaging.

Original language	English (US)
Pages (from-to)	231-244
Number of pages	14
Journal	Expert Review of Molecular Diagnostics
Volume	6
Issue number	2
DOIs	https://doi.org/10.1586/14737159.6.2.231
State	Published - 2006
Externally published	Yes

Keywords

Biosensor
Cancer
Imaging
Immunohistochemistry
In vivo
Multiplex
Nanotechnology
Quantum dot
Toxicity

ASJC Scopus subject areas

Genetics

Online availability

10.1586/14737159.6.2.231

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title = "Multicolor quantum dots for molecular diagnostics of cancer",

abstract = "In the pursuit of sensitive and quantitative methods to detect and diagnose cancer, nanotechnology has been identified as a field of great promise. Semiconductor quantum dots are nanoparticles with intense, stable fluorescence, and could enable the detection of tens to hundreds of cancer biomarkers in blood assays, on cancer tissue biopsies, or as contrast agents for medical imaging. With the emergence of gene and protein profiling and microarray technology, high-throughput screening of biomarkers has generated databases of genomic and expression data for certain cancer types, and has identified new cancer-specific markers. Quantum dots have the potential to expand this in vitro analysis, and extend it to cellular, tissue and whole-body multiplexed cancer biomarker imaging.",

keywords = "Biosensor, Cancer, Imaging, Immunohistochemistry, In vivo, Multiplex, Nanotechnology, Quantum dot, Toxicity",

author = "Smith, {Andrew M.} and Shivang Dave and Shuming Nie and Lawrence True and Xiaohu Gao",

note = "Funding Information: Xiaohu Gao acknowledges the UW Bioengineering department for the startup fund. This work was also supported by a NIH-R01 grant awarded to Shuming Nie (GM60562). Andrew Smith acknowledges the Whitaker Foundation for fellowship support.",

year = "2006",

doi = "10.1586/14737159.6.2.231",

language = "English (US)",

volume = "6",

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AU - Smith, Andrew M.

AU - Dave, Shivang

AU - Nie, Shuming

AU - True, Lawrence

AU - Gao, Xiaohu

N1 - Funding Information: Xiaohu Gao acknowledges the UW Bioengineering department for the startup fund. This work was also supported by a NIH-R01 grant awarded to Shuming Nie (GM60562). Andrew Smith acknowledges the Whitaker Foundation for fellowship support.

PY - 2006

Y1 - 2006

N2 - In the pursuit of sensitive and quantitative methods to detect and diagnose cancer, nanotechnology has been identified as a field of great promise. Semiconductor quantum dots are nanoparticles with intense, stable fluorescence, and could enable the detection of tens to hundreds of cancer biomarkers in blood assays, on cancer tissue biopsies, or as contrast agents for medical imaging. With the emergence of gene and protein profiling and microarray technology, high-throughput screening of biomarkers has generated databases of genomic and expression data for certain cancer types, and has identified new cancer-specific markers. Quantum dots have the potential to expand this in vitro analysis, and extend it to cellular, tissue and whole-body multiplexed cancer biomarker imaging.

AB - In the pursuit of sensitive and quantitative methods to detect and diagnose cancer, nanotechnology has been identified as a field of great promise. Semiconductor quantum dots are nanoparticles with intense, stable fluorescence, and could enable the detection of tens to hundreds of cancer biomarkers in blood assays, on cancer tissue biopsies, or as contrast agents for medical imaging. With the emergence of gene and protein profiling and microarray technology, high-throughput screening of biomarkers has generated databases of genomic and expression data for certain cancer types, and has identified new cancer-specific markers. Quantum dots have the potential to expand this in vitro analysis, and extend it to cellular, tissue and whole-body multiplexed cancer biomarker imaging.

KW - Biosensor

KW - Cancer

KW - Imaging

KW - Immunohistochemistry

KW - In vivo

KW - Multiplex

KW - Nanotechnology

KW - Quantum dot

KW - Toxicity

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Multicolor quantum dots for molecular diagnostics of cancer

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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