Multicolor quantum dots for molecular diagnostics of cancer

Andrew M. Smith, Shivang Dave, Shuming Nie, Lawrence True, Xiaohu Gao

Research output: Contribution to journalReview article

Abstract

In the pursuit of sensitive and quantitative methods to detect and diagnose cancer, nanotechnology has been identified as a field of great promise. Semiconductor quantum dots are nanoparticles with intense, stable fluorescence, and could enable the detection of tens to hundreds of cancer biomarkers in blood assays, on cancer tissue biopsies, or as contrast agents for medical imaging. With the emergence of gene and protein profiling and microarray technology, high-throughput screening of biomarkers has generated databases of genomic and expression data for certain cancer types, and has identified new cancer-specific markers. Quantum dots have the potential to expand this in vitro analysis, and extend it to cellular, tissue and whole-body multiplexed cancer biomarker imaging.

Original languageEnglish (US)
Pages (from-to)231-244
Number of pages14
JournalExpert Review of Molecular Diagnostics
Volume6
Issue number2
DOIs
StatePublished - Aug 9 2006
Externally publishedYes

Keywords

  • Biosensor
  • Cancer
  • Imaging
  • Immunohistochemistry
  • In vivo
  • Multiplex
  • Nanotechnology
  • Quantum dot
  • Toxicity

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Multicolor quantum dots for molecular diagnostics of cancer'. Together they form a unique fingerprint.

  • Cite this