Multi-timescale hybrid components of the functional brain connectome: A bimodal eeg-fmri decomposition

Jonathan Wirsich, Enrico Amico, Anne Lise Giraud, Joaquín Goñi, Sepideh Sadaghiani

Research output: Contribution to journalArticlepeer-review

Abstract

Concurrent electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) bridge brain connectivity across timescales. During concurrent EEG-fMRI resting-state recordings, whole-brain functional connectivity (FC) strength is spatially correlated across modalities. However, cross-modal investigations have commonly remained correlational, and joint analysis of EEG-fMRI connectivity is largely unexplored. Here we investigated if there exist (spatially) independent FC networks linked between modalities. We applied the recently proposed hybrid connectivity independent component analysis (connICA) framework to two concurrent EEG-fMRI resting-state datasets (total 40 subjects). Two robust components were found across both datasets. The first component has a uniformly distributed EEG frequency fingerprint linked mainly to intrinsic connectivity networks (ICNs) in both modalities. Conversely, the second component is sensitive to different EEG frequencies and is primarily linked to intra-ICN connectivity in fMRI but to inter-ICN connectivity in EEG. The first hybrid component suggests that connectivity dynamics within well-known ICNs span timescales, from millisecond range in all canonical frequencies of FCEEG to second range of FCfMRI. Conversely, the second component additionally exposes linked but spatially divergent neuronal processing at the two timescales. This work reveals the existence of joint spatially independent components, suggesting that parts of resting-state connectivity are co-expressed in a linked manner across EEG and fMRI over individuals.

Original languageEnglish (US)
Pages (from-to)658-677
Number of pages20
JournalNetwork Neuroscience
Volume4
Issue number3
DOIs
StatePublished - 2020

Keywords

  • Brain connectivity
  • Concurrent EEG-fMRI
  • Human connectome
  • ICA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Computer Science Applications
  • Artificial Intelligence
  • Applied Mathematics

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