Multi-subunit acetyl-CoA carboxylases

John E. Cronan, Grover L. Waldrop

Research output: Contribution to journalReview articlepeer-review


Acetyl-CoA carboxylase (ACC) catalyses the first committed step of fatty acid synthesis, the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are found in nature. Bacterial and most plant chloroplasts contain a multi-subunit ACC (MS-ACC) enzyme that is readily dissociated into its component proteins. Mammals, fungi, and plant cytosols contain the second type of ACC, a single large multifunctional polypeptide. This review will focus on the structures, regulation, and enzymatic mechanisms of the bacterial and plant MS-ACCs.

Original languageEnglish (US)
Pages (from-to)407-435
Number of pages29
JournalProgress in Lipid Research
Issue number5
StatePublished - 2002

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology


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