TY - JOUR
T1 - Multi-subunit acetyl-CoA carboxylases
AU - Cronan, John E.
AU - Waldrop, Grover L.
PY - 2002
Y1 - 2002
N2 - Acetyl-CoA carboxylase (ACC) catalyses the first committed step of fatty acid synthesis, the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are found in nature. Bacterial and most plant chloroplasts contain a multi-subunit ACC (MS-ACC) enzyme that is readily dissociated into its component proteins. Mammals, fungi, and plant cytosols contain the second type of ACC, a single large multifunctional polypeptide. This review will focus on the structures, regulation, and enzymatic mechanisms of the bacterial and plant MS-ACCs.
AB - Acetyl-CoA carboxylase (ACC) catalyses the first committed step of fatty acid synthesis, the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are found in nature. Bacterial and most plant chloroplasts contain a multi-subunit ACC (MS-ACC) enzyme that is readily dissociated into its component proteins. Mammals, fungi, and plant cytosols contain the second type of ACC, a single large multifunctional polypeptide. This review will focus on the structures, regulation, and enzymatic mechanisms of the bacterial and plant MS-ACCs.
UR - http://www.scopus.com/inward/record.url?scp=0036018143&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036018143&partnerID=8YFLogxK
U2 - 10.1016/S0163-7827(02)00007-3
DO - 10.1016/S0163-7827(02)00007-3
M3 - Review article
C2 - 12121720
AN - SCOPUS:0036018143
SN - 0163-7827
VL - 41
SP - 407
EP - 435
JO - Progress in Lipid Research
JF - Progress in Lipid Research
IS - 5
ER -