Multi-Segment Reconstruction Using Invariant Features

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Multi-segment reconstruction (MSR) problem consists of recovering a signal from noisy segments with unknown positions of the observation windows. One example arises in DNA sequence assembly, which is typically solved by matching short reads to form longer sequences. Instead of trying to locate the segment within the sequence through pair-wise matching, we propose a new approach that uses shift-invariant features to estimate both the underlying signal and the distribution of the positions of the segments. Using the invariant features, we formulate the problem as a constrained nonlinear least-squares. The non-convexity of the problem leads to its sensitivity to the initialization. However, with clean data, we show empirically that for longer segment lengths, random initialization achieves exact recovery. Furthermore, we compare the performance of our approach to the results of expectation maximization and demonstrate that the new approach is robust to noise and computationally more efficient.

Original languageEnglish (US)
Title of host publication2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages4629-4633
Number of pages5
ISBN (Print)9781538646588
DOIs
StatePublished - Sep 10 2018
Event2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018 - Calgary, Canada
Duration: Apr 15 2018Apr 20 2018

Publication series

NameICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
Volume2018-April
ISSN (Print)1520-6149

Other

Other2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018
CountryCanada
CityCalgary
Period4/15/184/20/18

Keywords

  • Cryo-EM
  • DNA sequence assembly
  • Invariant features
  • Multi-segment reconstruction
  • Non-convex optimization

ASJC Scopus subject areas

  • Software
  • Signal Processing
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Multi-Segment Reconstruction Using Invariant Features'. Together they form a unique fingerprint.

  • Cite this

    Zehni, M., Do, M. N., & Zhao, Z. (2018). Multi-Segment Reconstruction Using Invariant Features. In 2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018 - Proceedings (pp. 4629-4633). [8461796] (ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings; Vol. 2018-April). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICASSP.2018.8461796