Abstract

We model trabecular bone as a nanocomposite material with hierarchical structure and predict its elastic properties at different structural scales. The analysis involves a bottom-up multi-scale approach, starting with nanoscale (mineralized collagen fibril) and moving up the scales to sub-microscale (single lamella), microscale (single trabecula) and mesoscale (trabecular bone) levels. Continuum micromechanics methods, composite materials laminate theory and finite-element methods are used in the analysis. Good agreement is found between theoretical and experimental results.

Original languageEnglish (US)
Pages (from-to)1654-1673
Number of pages20
JournalJournal of the Royal Society Interface
Volume9
Issue number72
DOIs
StatePublished - Jul 7 2012

Fingerprint

Elastic Modulus
Bone
Elastic moduli
Nanocomposites
Micromechanics
Collagen
Laminates
Finite element method
Composite materials
Cancellous Bone

Keywords

  • Elastic moduli
  • Hierarchical structure
  • MicroCT-based finite-element modelling
  • Multi-scale modelling
  • Nanocomposite
  • Trabecular bone

ASJC Scopus subject areas

  • Biophysics
  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials
  • Biochemistry

Cite this

Multi-scale modelling of elastic moduli of trabecular bone. / Hamed, Elham; Jasiuk, Iwona; Yoo, Andrew; Lee, YikHan; Liszka, Tadeusz.

In: Journal of the Royal Society Interface, Vol. 9, No. 72, 07.07.2012, p. 1654-1673.

Research output: Contribution to journalReview article

Hamed, Elham ; Jasiuk, Iwona ; Yoo, Andrew ; Lee, YikHan ; Liszka, Tadeusz. / Multi-scale modelling of elastic moduli of trabecular bone. In: Journal of the Royal Society Interface. 2012 ; Vol. 9, No. 72. pp. 1654-1673.
@article{8cd3f94e5b12452b978a95783aaee765,
title = "Multi-scale modelling of elastic moduli of trabecular bone",
abstract = "We model trabecular bone as a nanocomposite material with hierarchical structure and predict its elastic properties at different structural scales. The analysis involves a bottom-up multi-scale approach, starting with nanoscale (mineralized collagen fibril) and moving up the scales to sub-microscale (single lamella), microscale (single trabecula) and mesoscale (trabecular bone) levels. Continuum micromechanics methods, composite materials laminate theory and finite-element methods are used in the analysis. Good agreement is found between theoretical and experimental results.",
keywords = "Elastic moduli, Hierarchical structure, MicroCT-based finite-element modelling, Multi-scale modelling, Nanocomposite, Trabecular bone",
author = "Elham Hamed and Iwona Jasiuk and Andrew Yoo and YikHan Lee and Tadeusz Liszka",
year = "2012",
month = "7",
day = "7",
doi = "10.1098/rsif.2011.0814",
language = "English (US)",
volume = "9",
pages = "1654--1673",
journal = "Journal of the Royal Society Interface",
issn = "1742-5689",
publisher = "Royal Society of London",
number = "72",

}

TY - JOUR

T1 - Multi-scale modelling of elastic moduli of trabecular bone

AU - Hamed, Elham

AU - Jasiuk, Iwona

AU - Yoo, Andrew

AU - Lee, YikHan

AU - Liszka, Tadeusz

PY - 2012/7/7

Y1 - 2012/7/7

N2 - We model trabecular bone as a nanocomposite material with hierarchical structure and predict its elastic properties at different structural scales. The analysis involves a bottom-up multi-scale approach, starting with nanoscale (mineralized collagen fibril) and moving up the scales to sub-microscale (single lamella), microscale (single trabecula) and mesoscale (trabecular bone) levels. Continuum micromechanics methods, composite materials laminate theory and finite-element methods are used in the analysis. Good agreement is found between theoretical and experimental results.

AB - We model trabecular bone as a nanocomposite material with hierarchical structure and predict its elastic properties at different structural scales. The analysis involves a bottom-up multi-scale approach, starting with nanoscale (mineralized collagen fibril) and moving up the scales to sub-microscale (single lamella), microscale (single trabecula) and mesoscale (trabecular bone) levels. Continuum micromechanics methods, composite materials laminate theory and finite-element methods are used in the analysis. Good agreement is found between theoretical and experimental results.

KW - Elastic moduli

KW - Hierarchical structure

KW - MicroCT-based finite-element modelling

KW - Multi-scale modelling

KW - Nanocomposite

KW - Trabecular bone

UR - http://www.scopus.com/inward/record.url?scp=84863596030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863596030&partnerID=8YFLogxK

U2 - 10.1098/rsif.2011.0814

DO - 10.1098/rsif.2011.0814

M3 - Review article

C2 - 22279160

AN - SCOPUS:84863596030

VL - 9

SP - 1654

EP - 1673

JO - Journal of the Royal Society Interface

JF - Journal of the Royal Society Interface

SN - 1742-5689

IS - 72

ER -