We model trabecular bone as a nanocomposite material with hierarchical structure and predict its elastic properties at different structural scales. The analysis involves a bottom-up multi-scale approach, starting with nanoscale (mineralized collagen fibril) and moving up the scales to sub-microscale (single lamella), microscale (single trabecula) and mesoscale (trabecular bone) levels. Continuum micromechanics methods, composite materials laminate theory and finite-element methods are used in the analysis. Good agreement is found between theoretical and experimental results.

Original languageEnglish (US)
Pages (from-to)1654-1673
Number of pages20
JournalJournal of the Royal Society Interface
Issue number72
StatePublished - Jul 7 2012


  • Elastic moduli
  • Hierarchical structure
  • MicroCT-based finite-element modelling
  • Multi-scale modelling
  • Nanocomposite
  • Trabecular bone

ASJC Scopus subject areas

  • Biophysics
  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials
  • Biochemistry


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