Future large-scale space exploration and commercialization require extensive cooperation and federation among multiple government and commercial entities. The necessary resources and technologies to complete a space mission efficiently may not be owned by a single actor. Thus, an effective evaluation of space architectures performance needs to consider both local incentives (i.e., benefits to the owner) and interaction effects among independent actors (i.e., risk of successful implementation). This paper proposes a multi-actor logistics network model based on game theory to explore performance and commercialization potential of space architectures under multi-actor decision-making environment. Results from a human cislunar exploration case study reveal the effectiveness of the proposed framework. It provides an innovative perspective on space architecture commercialization analysis.