MSC Studies in Large-Animal Models

Bruce A. Bunnell; Christine Gagliardi; Maria Isabel Ribeiro Dias

doi:10.1007/978-1-4614-5711-4_13

MSC Studies in Large-Animal Models

Bruce A. Bunnell
, Christine Gagliardi
, Maria Isabel Ribeiro Dias

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Mesenchymal stromal cells found within bone marrow, fat, and other tissues are a population of cells with the potential to mediate therapeutic outcomes based on differentiation into multiple cell lineages or through paracrine-mediated mechanisms that influence angiogenesis, apoptosis, or immune response. Currently, mesenchymal stromal cells are being widely investigated for numerous tissue engineering and regenerative medicine applications. Appropriate animal models will be crucial to the development and evaluation of regenerative medicine-based treatments and eventual cures for debilitating diseases. Here, we summarize the ongoing research focused on studying the biological and therapeutic potential of mesenchymal stromal cells in large-animal models.

Original language	English (US)
Title of host publication	Mesenchymal Stromal Cells
Subtitle of host publication	Biology and Clinical Applications
Publisher	Springer
Pages	237-258
Number of pages	22
ISBN (Electronic)	9781461457114
ISBN (Print)	9781461457107
DOIs	https://doi.org/10.1007/978-1-4614-5711-4_13
State	Published - 2013
Externally published	Yes

Publication series

Name	Stem Cell Biology and Regenerative Medicine
Volume	Part F4869
ISSN (Print)	2196-8985
ISSN (Electronic)	2196-8993

Keywords

Bone Regeneration
Canine Model
Cynomolgus Monkey
Human MSCs
Mesenchymal Stromal Cell

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Online availability

10.1007/978-1-4614-5711-4_13

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title = "MSC Studies in Large-Animal Models",

abstract = "Mesenchymal stromal cells found within bone marrow, fat, and other tissues are a population of cells with the potential to mediate therapeutic outcomes based on differentiation into multiple cell lineages or through paracrine-mediated mechanisms that influence angiogenesis, apoptosis, or immune response. Currently, mesenchymal stromal cells are being widely investigated for numerous tissue engineering and regenerative medicine applications. Appropriate animal models will be crucial to the development and evaluation of regenerative medicine-based treatments and eventual cures for debilitating diseases. Here, we summarize the ongoing research focused on studying the biological and therapeutic potential of mesenchymal stromal cells in large-animal models.",

keywords = "Bone Regeneration, Canine Model, Cynomolgus Monkey, Human MSCs, Mesenchymal Stromal Cell",

author = "Bunnell, \{Bruce A.\} and Christine Gagliardi and Dias, \{Maria Isabel Ribeiro\}",

note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2013.",

year = "2013",

doi = "10.1007/978-1-4614-5711-4\_13",

language = "English (US)",

isbn = "9781461457107",

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T1 - MSC Studies in Large-Animal Models

AU - Bunnell, Bruce A.

AU - Gagliardi, Christine

AU - Dias, Maria Isabel Ribeiro

N1 - Publisher Copyright: © Springer Science+Business Media New York 2013.

PY - 2013

Y1 - 2013

N2 - Mesenchymal stromal cells found within bone marrow, fat, and other tissues are a population of cells with the potential to mediate therapeutic outcomes based on differentiation into multiple cell lineages or through paracrine-mediated mechanisms that influence angiogenesis, apoptosis, or immune response. Currently, mesenchymal stromal cells are being widely investigated for numerous tissue engineering and regenerative medicine applications. Appropriate animal models will be crucial to the development and evaluation of regenerative medicine-based treatments and eventual cures for debilitating diseases. Here, we summarize the ongoing research focused on studying the biological and therapeutic potential of mesenchymal stromal cells in large-animal models.

AB - Mesenchymal stromal cells found within bone marrow, fat, and other tissues are a population of cells with the potential to mediate therapeutic outcomes based on differentiation into multiple cell lineages or through paracrine-mediated mechanisms that influence angiogenesis, apoptosis, or immune response. Currently, mesenchymal stromal cells are being widely investigated for numerous tissue engineering and regenerative medicine applications. Appropriate animal models will be crucial to the development and evaluation of regenerative medicine-based treatments and eventual cures for debilitating diseases. Here, we summarize the ongoing research focused on studying the biological and therapeutic potential of mesenchymal stromal cells in large-animal models.

KW - Bone Regeneration

KW - Canine Model

KW - Cynomolgus Monkey

KW - Human MSCs

KW - Mesenchymal Stromal Cell

UR - https://www.scopus.com/pages/publications/85028501691

UR - https://www.scopus.com/pages/publications/85028501691#tab=citedBy

U2 - 10.1007/978-1-4614-5711-4_13

DO - 10.1007/978-1-4614-5711-4_13

M3 - Chapter

AN - SCOPUS:85028501691

SN - 9781461457107

T3 - Stem Cell Biology and Regenerative Medicine

SP - 237

EP - 258

BT - Mesenchymal Stromal Cells

PB - Springer

ER -

MSC Studies in Large-Animal Models

Abstract

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ASJC Scopus subject areas

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