MRI detection of thrombin with aptamer functionalized superparamagnetic iron oxide nanoparticles

Mehmet Veysel Yigit, Debapriya Mazumdar, Yi Lu

Research output: Contribution to journalArticle

Abstract

Design of smart MRI contrast agent based on superparamagnetic iron oxide nanoparticles and aptamers has been described for the detection of human α-thrombin protein. The contrast agent is based on the assembly of the aptamer functionalized nanoparticles in the presence of thrombin. A detectable change in MRI signal is observed with 25 nM thrombin in human serum. Changes were neither observed with control analytes, streptavidin, or bovine serum albumin, nor with inactive aptamer functionalized nanoparticles.

Original languageEnglish (US)
Pages (from-to)412-417
Number of pages6
JournalBioconjugate Chemistry
Volume19
Issue number2
DOIs
StatePublished - Feb 1 2008

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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