Moving chromatin within the interphase nucleus-controlled transitions?

Chien Hui Chuang, Andrew S. Belmont

Research output: Contribution to journalReview article

Abstract

The past decade has seen an increasing appreciation for nuclear compartmentalization as an underlying determinant of interphase chromosome nuclear organization. To date, attention has focused primarily on describing differential localization of particular genes or chromosome regions as a function of differentiation, cell cycle position, and/or transcriptional activity. The question of how exactly interphase chromosome compartmentalization is established and in particular how interphase chromosomes might move during changes in nuclear compartmentalization has received less attention. Here we review what is known concerning chromatin mobility in relationship to physiologically regulated changes in nuclear interphase chromosome organization.

Original languageEnglish (US)
Pages (from-to)698-706
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume18
Issue number5
DOIs
StatePublished - Oct 2007

Keywords

  • Chromatin mobility
  • Interphase chromosome
  • Nuclear organization

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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