@article{c8e0cdeb24ec403eacedb12255b7d1a9,
title = "Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors",
abstract = "Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have harnessed the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence that SARS-CoV-2 exists as locally evolving variants suggests that immunological differences may impact the effectiveness of antibody-based treatments such as convalescent plasma and vaccines. Considering that near-sourced convalescent plasma likely reflects the antigenic composition of local viral strains, we hypothesize that convalescent plasma has a higher efficacy, as defined by death within 30 days of transfusion, when the convalescent plasma donor and treated patient were in close geographic proximity. Results of a series of modeling techniques applied to approximately 28,000 patients from the Expanded Access to Convalescent Plasma program (ClinicalTrials.gov number: NCT04338360) support this hypothesis. This work has implications for the interpretation of clinical studies, the ability to develop effective COVID-19 treatments, and, potentially, for the effectiveness of COVID-19 vaccines as additional locally-evolving variants continue to emerge.",
author = "Kunze, {Katie L.} and Johnson, {Patrick W.} and {van Helmond}, Noud and Senefeld, {Jonathon W.} and Petersen, {Molly M.} and Klassen, {Stephen A.} and Wiggins, {Chad C.} and Klompas, {Allan M.} and Bruno, {Katelyn A.} and Mills, {John R.} and Theel, {Elitza S.} and Buras, {Matthew R.} and Golafshar, {Michael A.} and Sexton, {Matthew A.} and {Diaz Soto}, {Juan C.} and Baker, {Sarah E.} and Shepherd, {John R.A.} and Verdun, {Nicole C.} and Peter Marks and Paneth, {Nigel S.} and Fairweather, {De Lisa} and Wright, {R. Scott} and {van Buskirk}, {Camille M.} and Winters, {Jeffrey L.} and Stubbs, {James R.} and Senese, {Katherine A.} and Pletsch, {Michaela C.} and Buchholtz, {Zachary A.} and Rea, {Robert F.} and Vitaly Herasevich and Whelan, {Emily R.} and Clayburn, {Andrew J.} and Larson, {Kathryn F.} and Ripoll, {Juan G.} and Andersen, {Kylie J.} and Lesser, {Elizabeth R.} and Vogt, {Matthew N.P.} and Dennis, {Joshua J.} and Regimbal, {Riley J.} and Bauer, {Philippe R.} and Blair, {Janis E.} and Arturo Casadevall and Carter, {Rickey E.} and Joyner, {Michael J.}",
note = "Funding Information: This project has been funded in part with Federal funds from the Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response, and Biomedical Advanced Research and Development Authority under Contract No. 75A50120C00096. Additionally, this study was supported in part by National Center for Advancing Translational Sciences (NCATS) grant UL1TR002377, National Heart, Lung, and Blood Institute (NHLBI) grant 5R35HL139854 (to M.J.J.) and grant 1F32HL154320 (to J.W.S.), Natural Sciences and Engineering Research Council of Canada (NSERC) PDF-532926-2019 (to S.A.K.), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 5T32DK07352 (to C.C.W.), National Institute of Allergy and Infectious Disease (NIAID) grants R21 AI145356, R21 AI152318, and R21 AI154927 (to D.F.), R01 AI152078 9 (to A.C.), National Heart Lung and Blood Institute RO1 HL059842 (to A.C.), National Institute on Aging (NIA) U54AG044170 (to S.E.B.), Schwab Charitable Fund (Eric E Schmidt, Wendy Schmidt donors), United Health Group, National Basketball Association (NBA), Millennium Pharmaceuticals, Octapharma USA, Inc., and the Mayo Clinic. Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = dec,
day = "1",
doi = "10.1038/s41467-021-25113-5",
language = "English (US)",
volume = "12",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Research",
number = "1",
}