Research output per year
Research output per year
Matthew A. Wallig, Evan B. Janovitz
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Whatever causes injury to a cell—toxicant, toxin, infectious agent, or otherwise—the result is a simple or complex biochemical shift that generally results in a morphologic change which can be observed in some form. The pathologist must be able to recognize that such changes in morphology reflect a significant alteration in the cell's homeostasis, as sometimes altered morphology has no impact on cellular function. The first step is to determine whether the abnormal morphology is harmful to the cell or tissue. By determining whether the primary morphological change is one of degeneration, inflammation, or neoplasia, the next step is to determine whether this finding indicates reversible injury, irreversible injury, or adaptation to the new situation. Visible manifestations of disrupted function, whether ultrastructural, microscopic, or macroscopic, are lesions by definition, and lesions are still the primary means by which a toxicologic pathologist arrives at a diagnosis, hopefully one that includes the etiology as well as a description of the underlying morphologic alterations and a plausible pathogenesis of how the lesions came about. This chapter will serve as an overview of the basic histologic and ultrastructural features that reflect cell injury and death as well as the sequelae to such processes.
Original language | English (US) |
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Title of host publication | Haschek and Rousseaux's Handbook of Toxicologic Pathology |
Editors | Wanda M Haschek, Colin G Rousseaux, Matthew A Wallig, Brad Bolon |
Publisher | Academic Press |
Pages | 113-148 |
Number of pages | 36 |
Volume | 1 |
Edition | 4 |
ISBN (Electronic) | 9780128210444 |
ISBN (Print) | 9780128218297 |
DOIs | |
State | Published - Jan 1 2021 |
Research output: Book/Report/Conference proceeding › Book