Monthly injectable contraceptives and the risk of all cancers combined and site-specific cancers in Shanghai

Karin A. Rosenblatt, Dao L. Gao, Roberta M. Ray, Zakia C. Nelson, Karen J. Wernli, Wenjin Li, David B. Thomas

Research output: Contribution to journalArticle

Abstract

Purpose: The risk of 12 types of cancer in relation to use of monthly injectable contraceptives was assessed in a prospective study in Shanghai, China. Methods: From 1989 to 1991, an in-person interview was administered to 267,400 female textile workers to ascertain information on risk factors for breast cancer, contraceptive use and induced abortions. The cohort was followed until July 2000 for incident cancer cases. Cox proportional hazards analysis was used to calculate incidence rate ratios for specific types of cancer in women who ever had used monthly injectable contraceptives and by length of use. Results: There was a reduced risk of uterine corpus cancer for women who had ever used monthly injectable contraceptives. No association was observed between the use of monthly injectable contraceptives and the risk of all cancers combined and for any of the 11 other cancersconsidered. Conclusion: There appears to be no evidence of an increased risk of cancer after exposure to monthly injectable contraceptives in our study.

Original languageEnglish (US)
Pages (from-to)40-44
Number of pages5
JournalContraception
Volume76
Issue number1
DOIs
StatePublished - Jul 1 2007

Keywords

  • Cohort studies
  • Monthly injectable contraceptives
  • Neoplasms

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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