TY - JOUR
T1 - Monosodium [1-hydroxy-2-(1H-imidazol-3-ium-4-yl)ethane-1,1-diyl]-bis(phosphonate) tetrahydrate (monosodium isozoledronate)
AU - Gossman, William L.
AU - Wilson, Scott R.
AU - Oldfield, Eric
PY - 2002/12
Y1 - 2002/12
N2 - The title compound, Na+·C5H9N2O7P 2-·4H2O, is an isomer of zoledronate, a potent bone antiresorptive bisphosphonate drug having significant activity against several parasitic protozoa. The crystal structure of isozoledronate consists of bisphosphonate dimers coordinated by two Na+ ions. The dimers are held together through an extensive hydrogen-bonding network. The crystals exhibit non-merohedral twinning that roughly superimposes the a and b axes, and inverts the c axis.
AB - The title compound, Na+·C5H9N2O7P 2-·4H2O, is an isomer of zoledronate, a potent bone antiresorptive bisphosphonate drug having significant activity against several parasitic protozoa. The crystal structure of isozoledronate consists of bisphosphonate dimers coordinated by two Na+ ions. The dimers are held together through an extensive hydrogen-bonding network. The crystals exhibit non-merohedral twinning that roughly superimposes the a and b axes, and inverts the c axis.
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U2 - 10.1107/S0108270102019522
DO - 10.1107/S0108270102019522
M3 - Article
C2 - 12466610
AN - SCOPUS:0036960046
SN - 0108-2701
VL - 58
SP - m599-m600
JO - Acta Crystallographica, Section C: Crystal Structure Communications
JF - Acta Crystallographica, Section C: Crystal Structure Communications
IS - 12
ER -