Monosodium [1-hydroxy-2-(1H-imidazol-3-ium-4-yl)ethane-1,1-diyl]-bis(phosphonate) tetrahydrate (monosodium isozoledronate)

William L. Gossman; Scott R. Wilson; Eric Oldfield

doi:10.1107/S0108270102019522

Monosodium [1-hydroxy-2-(1H-imidazol-3-ium-4-yl)ethane-1,1-diyl]-bis(phosphonate) tetrahydrate (monosodium isozoledronate)

William L. Gossman, Scott R. Wilson, Eric Oldfield

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The title compound, Na⁺·C₅H₉N₂O₇P₂^-·4H₂O, is an isomer of zoledronate, a potent bone antiresorptive bisphosphonate drug having significant activity against several parasitic protozoa. The crystal structure of isozoledronate consists of bisphosphonate dimers coordinated by two Na⁺ ions. The dimers are held together through an extensive hydrogen-bonding network. The crystals exhibit non-merohedral twinning that roughly superimposes the a and b axes, and inverts the c axis.

Original language	English (US)
Pages (from-to)	m599-m600
Journal	Acta Crystallographica Section C: Crystal Structure Communications
Volume	58
Issue number	12
DOIs	https://doi.org/10.1107/S0108270102019522
State	Published - Dec 2002

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1107/S0108270102019522

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abstract = "The title compound, Na+·C5H9N2O7P 2-·4H2O, is an isomer of zoledronate, a potent bone antiresorptive bisphosphonate drug having significant activity against several parasitic protozoa. The crystal structure of isozoledronate consists of bisphosphonate dimers coordinated by two Na+ ions. The dimers are held together through an extensive hydrogen-bonding network. The crystals exhibit non-merohedral twinning that roughly superimposes the a and b axes, and inverts the c axis.",

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T1 - Monosodium [1-hydroxy-2-(1H-imidazol-3-ium-4-yl)ethane-1,1-diyl]-bis(phosphonate) tetrahydrate (monosodium isozoledronate)

AU - Gossman, William L.

AU - Wilson, Scott R.

AU - Oldfield, Eric

PY - 2002/12

Y1 - 2002/12

N2 - The title compound, Na+·C5H9N2O7P 2-·4H2O, is an isomer of zoledronate, a potent bone antiresorptive bisphosphonate drug having significant activity against several parasitic protozoa. The crystal structure of isozoledronate consists of bisphosphonate dimers coordinated by two Na+ ions. The dimers are held together through an extensive hydrogen-bonding network. The crystals exhibit non-merohedral twinning that roughly superimposes the a and b axes, and inverts the c axis.

AB - The title compound, Na+·C5H9N2O7P 2-·4H2O, is an isomer of zoledronate, a potent bone antiresorptive bisphosphonate drug having significant activity against several parasitic protozoa. The crystal structure of isozoledronate consists of bisphosphonate dimers coordinated by two Na+ ions. The dimers are held together through an extensive hydrogen-bonding network. The crystals exhibit non-merohedral twinning that roughly superimposes the a and b axes, and inverts the c axis.

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Monosodium [1-hydroxy-2-(1H-imidazol-3-ium-4-yl)ethane-1,1-diyl]-bis(phosphonate) tetrahydrate (monosodium isozoledronate)

Abstract

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