Monosodium [1-hydroxy-2-(1H-imidazol-3-ium-4-yl)ethane-1,1-diyl]-bis(phosphonate) tetrahydrate (monosodium isozoledronate)

William L. Gossman, Scott R. Wilson, Eric Oldfield

Research output: Contribution to journalArticlepeer-review


The title compound, Na+·C5H9N2O7P 2-·4H2O, is an isomer of zoledronate, a potent bone antiresorptive bisphosphonate drug having significant activity against several parasitic protozoa. The crystal structure of isozoledronate consists of bisphosphonate dimers coordinated by two Na+ ions. The dimers are held together through an extensive hydrogen-bonding network. The crystals exhibit non-merohedral twinning that roughly superimposes the a and b axes, and inverts the c axis.

Original languageEnglish (US)
Pages (from-to)m599-m600
JournalActa Crystallographica Section C: Crystal Structure Communications
Issue number12
StatePublished - Dec 2002

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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