Monocytes and macrophages in atherogenesis

Jaume Amengual, Tessa J. Barrett

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of reviewMonocytes and macrophages are key players in the pathogenesis of atherosclerosis and dictate atherogenesis growth and stability. The heterogeneous nature of myeloid cells concerning their metabolic and phenotypic function is increasingly appreciated. This review summarizes the recent monocyte and macrophage literature and highlights how differing subsets contribute to atherogenesis.Recent findingsMonocytes are short-lived cells generated in the bone marrow and released to circulation where they can produce inflammatory cytokines and, importantly, differentiate into long-lived macrophages. In the context of cardiovascular disease, a myriad of subtypes, exist with each differentially contributing to plaque development. Herein we describe recent novel characterizations of monocyte and macrophage subtypes and summarize the recent literature on mediators of myelopoiesis.SummaryAn increased understanding of monocyte and macrophage phenotype and their molecular regulators is likely to translate to the development of new therapeutic targets to either stem the growth of existing plaques or promote plaque stabilization.

Original languageEnglish (US)
Pages (from-to)401-408
Number of pages8
JournalCurrent Opinion in Lipidology
Volume30
Issue number5
DOIs
StatePublished - Oct 1 2019

Keywords

  • atherosclerosis
  • macrophage
  • monocyte

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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